Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity

Understanding the mechanism of action (MOA) of bioactive natural products will guide endeavor to improve their cellular activities. Artemisinin and its derivatives inhibit cancer cell proliferation, yet with much lower efficiencies than their roles in killing malaria parasites. To improve their effi...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-10, Vol.55 (44), p.13770-13774
Hauptverfasser:	Zhang, Chong-Jing, Wang, Jigang, Zhang, Jianbin, Lee, Yew Mun, Feng, Guangxue, Lim, Teck Kwang, Shen, Han-Ming, Lin, Qingsong, Liu, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs anticancer activity Anticancer properties Antitumor activity Artemisinin Attachment Biocompatibility Biomedical materials Cancer Cell proliferation Derivatives Design Design improvements Design optimization drug delivery Drug development fluorescent probe Heme Inhibition Malaria Mitochondria mitochondria targeting Natural products Parasites Proteins Proteomics Surgical implants Transcription factors triphenylphosphonium Vector-borne diseases
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