Baclofen Solution for Low‐Volume Therapeutic Delivery

Objectives Baclofen is a zwitterion molecule where increased ions in the excipient increase the solubility. We developed baclofen in a stable solution similar to cerebrospinal fluid (CSF) without bicarbonate and proteins to improve the solubility of the baclofen and to reduce the potential toxicity...

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Veröffentlicht in:	Neuromodulation (Malden, Mass.) Mass.), 2017-06, Vol.20 (4), p.392-396
Hauptverfasser:	Meythaler, Jay M., Peduzzi, Jean D.
Format:	Artikel
Sprache:	eng
Schlagworte:	artificial CSF Baclofen Baclofen - administration & dosage Baclofen - chemistry Bicarbonates Central nervous system Cerebrospinal fluid Colony-stimulating factor Drug Delivery Systems - methods Drug Delivery Systems - standards Drug Stability High-performance liquid chromatography Humans Humidity Infusion Pumps, Implantable intrathecal Ions Liquid chromatography Muscle Relaxants, Central - administration & dosage Muscle Relaxants, Central - chemistry Pharmaceutical Solutions - administration & dosage Pharmaceutical Solutions - chemistry Solubility spastic hypertonia spasticity Subarachnoid space Toxicity
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