Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study
Glutathione S.transferases. (GSTs) are known to play a pivotal role in the detoxification of potential carcinogens, and their gene variation may alter susceptibility to colorectal cancer. (CRC). The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymo...
Gespeichert in:
| Veröffentlicht in: | Indian journal of cancer 2016-10, Vol.53 (4), p.524 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | 524 |
| container_title | Indian journal of cancer |
| container_volume | 53 |
| creator | Nissar, S Sameer, A S Rasool, R Chowdri, N A Rashid, F |
| description | Glutathione S.transferases. (GSTs) are known to play a pivotal role in the detoxification of potential carcinogens, and their gene variation may alter susceptibility to colorectal cancer. (CRC). The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymorphism with disease susceptibility and risk development in CRC patients of ethnic Kashmiri population.
Genotype frequencies of GSTM1 and GSTT1 gene deletion/null polymorphism were compared between 160 CRC patients and 200 healthy controls using polymerase chain reaction multiplex.
The frequency of GSTM1-null was found to be 76.2% in cases and 81.5% in controls and odds ratio. (OR) = 1.37 (95% confidence interval. [CI]: 0.82-2.28). Likewise, the GSTT1-null genotype was found in 75.5% of cases and 77.5% of controls and the OR = 1.14 (95% CI: 0.76-1.8). The overall association between the GSTM1-null and GSTT1-null polymorphism and the CRC cases was found to be insignificant (P < 0.05). However, individuals with double-null genotype (GSTM1-/GSTT1-) were found to have 3.5-fold increased risk for the development of CRC. Further, the risk genotype (null) of GSTT1 was found to be associated with tumor grade (P = 0.001) and GSTM1 (null) genotype was significantly associated with smoking status (P = 0.004), when compared to the (present) genotype in CRC cases.
Our results suggest that GSTM1 and GSTT1 gene deletion/null gene polymorphisms are not a key modulators of the risk of developing CRC in Kashmiri population. |
| doi_str_mv | 10.4103/ijc.IJC_17_17 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1903885667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1903885667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-20c5b73124d5f1c8bfd04cd26132b7f128c4cefb171c2641019cec4e076d95f33</originalsourceid><addsrcrecordid>eNo9kVtrFTEUhYMo9rT10VcJ-Dw1t7n5Vg61rRZ8UKFvQ2bPTk-OmWRMMsL5I_7ephcLG_aG9bE2rEXIe87OFGfyk93D2fXX7cDbMq_Ihvd9V6m2Va_JhjHeVzXrb4_IcUp7xoQUqntLjkSnuloquSH_Lv5qt-psg6fB0AkdPt5LcIc5xGVn05welDu3Zp13RUP6o8pR-2Qw6oT0Dj0mqv1EIbgQEbJ2FLQHjDTa9JtaTzHvvAX6TafdbKMt9svqHr9-pucFTlhB8DkGR1Nep8MpeWO0S_jueZ-QX18ufm6vqpvvl9fb85sKpOC5EgzqsZVcqKk2HLrRTEzBJBouxdgaLjpQgGbkLQfRlLx4DwgKWdtMfW2kPCEfn3yXGP6smPKwD2v05eXAeya7rm6atlDVEwUxpBTRDEu0s46HgbPhoYWhtDC8tFD4D8-u6zjj9EL_j13eA0phhzI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1903885667</pqid></control><display><type>article</type><title>Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study</title><source>MEDLINE</source><source>Medknow Open Access Journals</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Nissar, S ; Sameer, A S ; Rasool, R ; Chowdri, N A ; Rashid, F</creator><creatorcontrib>Nissar, S ; Sameer, A S ; Rasool, R ; Chowdri, N A ; Rashid, F</creatorcontrib><description>Glutathione S.transferases. (GSTs) are known to play a pivotal role in the detoxification of potential carcinogens, and their gene variation may alter susceptibility to colorectal cancer. (CRC). The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymorphism with disease susceptibility and risk development in CRC patients of ethnic Kashmiri population.
Genotype frequencies of GSTM1 and GSTT1 gene deletion/null polymorphism were compared between 160 CRC patients and 200 healthy controls using polymerase chain reaction multiplex.
The frequency of GSTM1-null was found to be 76.2% in cases and 81.5% in controls and odds ratio. (OR) = 1.37 (95% confidence interval. [CI]: 0.82-2.28). Likewise, the GSTT1-null genotype was found in 75.5% of cases and 77.5% of controls and the OR = 1.14 (95% CI: 0.76-1.8). The overall association between the GSTM1-null and GSTT1-null polymorphism and the CRC cases was found to be insignificant (P < 0.05). However, individuals with double-null genotype (GSTM1-/GSTT1-) were found to have 3.5-fold increased risk for the development of CRC. Further, the risk genotype (null) of GSTT1 was found to be associated with tumor grade (P = 0.001) and GSTM1 (null) genotype was significantly associated with smoking status (P = 0.004), when compared to the (present) genotype in CRC cases.
Our results suggest that GSTM1 and GSTT1 gene deletion/null gene polymorphisms are not a key modulators of the risk of developing CRC in Kashmiri population.</description><identifier>ISSN: 0019-509X</identifier><identifier>EISSN: 1998-4774</identifier><identifier>DOI: 10.4103/ijc.IJC_17_17</identifier><identifier>PMID: 28485343</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt. Ltd</publisher><subject>Adult ; Aged ; Amino acids ; Asian Continental Ancestry Group - genetics ; Biochemistry ; Case-Control Studies ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Deoxyribonucleic acid ; Diabetes ; DNA ; Enzymes ; Female ; Genes ; Genetic Predisposition to Disease ; Genetic testing ; Genotype ; Genotype & phenotype ; Glutathione Transferase - genetics ; Humans ; Immunology ; India ; Male ; Metabolism ; Metabolites ; Middle Aged ; Odds Ratio ; Patients ; Polymorphism, Single Nucleotide ; Population ; Quality control ; Sample size ; Studies</subject><ispartof>Indian journal of cancer, 2016-10, Vol.53 (4), p.524</ispartof><rights>Copyright Medknow Publications & Media Pvt. Ltd. Oct/Dec 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-20c5b73124d5f1c8bfd04cd26132b7f128c4cefb171c2641019cec4e076d95f33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28485343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nissar, S</creatorcontrib><creatorcontrib>Sameer, A S</creatorcontrib><creatorcontrib>Rasool, R</creatorcontrib><creatorcontrib>Chowdri, N A</creatorcontrib><creatorcontrib>Rashid, F</creatorcontrib><title>Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study</title><title>Indian journal of cancer</title><addtitle>Indian J Cancer</addtitle><description>Glutathione S.transferases. (GSTs) are known to play a pivotal role in the detoxification of potential carcinogens, and their gene variation may alter susceptibility to colorectal cancer. (CRC). The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymorphism with disease susceptibility and risk development in CRC patients of ethnic Kashmiri population.
Genotype frequencies of GSTM1 and GSTT1 gene deletion/null polymorphism were compared between 160 CRC patients and 200 healthy controls using polymerase chain reaction multiplex.
The frequency of GSTM1-null was found to be 76.2% in cases and 81.5% in controls and odds ratio. (OR) = 1.37 (95% confidence interval. [CI]: 0.82-2.28). Likewise, the GSTT1-null genotype was found in 75.5% of cases and 77.5% of controls and the OR = 1.14 (95% CI: 0.76-1.8). The overall association between the GSTM1-null and GSTT1-null polymorphism and the CRC cases was found to be insignificant (P < 0.05). However, individuals with double-null genotype (GSTM1-/GSTT1-) were found to have 3.5-fold increased risk for the development of CRC. Further, the risk genotype (null) of GSTT1 was found to be associated with tumor grade (P = 0.001) and GSTM1 (null) genotype was significantly associated with smoking status (P = 0.004), when compared to the (present) genotype in CRC cases.
Our results suggest that GSTM1 and GSTT1 gene deletion/null gene polymorphisms are not a key modulators of the risk of developing CRC in Kashmiri population.</description><subject>Adult</subject><subject>Aged</subject><subject>Amino acids</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biochemistry</subject><subject>Case-Control Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic testing</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>India</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Quality control</subject><subject>Sample size</subject><subject>Studies</subject><issn>0019-509X</issn><issn>1998-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo9kVtrFTEUhYMo9rT10VcJ-Dw1t7n5Vg61rRZ8UKFvQ2bPTk-OmWRMMsL5I_7ephcLG_aG9bE2rEXIe87OFGfyk93D2fXX7cDbMq_Ihvd9V6m2Va_JhjHeVzXrb4_IcUp7xoQUqntLjkSnuloquSH_Lv5qt-psg6fB0AkdPt5LcIc5xGVn05welDu3Zp13RUP6o8pR-2Qw6oT0Dj0mqv1EIbgQEbJ2FLQHjDTa9JtaTzHvvAX6TafdbKMt9svqHr9-pucFTlhB8DkGR1Nep8MpeWO0S_jueZ-QX18ufm6vqpvvl9fb85sKpOC5EgzqsZVcqKk2HLrRTEzBJBouxdgaLjpQgGbkLQfRlLx4DwgKWdtMfW2kPCEfn3yXGP6smPKwD2v05eXAeya7rm6atlDVEwUxpBTRDEu0s46HgbPhoYWhtDC8tFD4D8-u6zjj9EL_j13eA0phhzI</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Nissar, S</creator><creator>Sameer, A S</creator><creator>Rasool, R</creator><creator>Chowdri, N A</creator><creator>Rashid, F</creator><general>Medknow Publications & Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20161001</creationdate><title>Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study</title><author>Nissar, S ; Sameer, A S ; Rasool, R ; Chowdri, N A ; Rashid, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-20c5b73124d5f1c8bfd04cd26132b7f128c4cefb171c2641019cec4e076d95f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amino acids</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biochemistry</topic><topic>Case-Control Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic testing</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Immunology</topic><topic>India</topic><topic>Male</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Quality control</topic><topic>Sample size</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nissar, S</creatorcontrib><creatorcontrib>Sameer, A S</creatorcontrib><creatorcontrib>Rasool, R</creatorcontrib><creatorcontrib>Chowdri, N A</creatorcontrib><creatorcontrib>Rashid, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Indian journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nissar, S</au><au>Sameer, A S</au><au>Rasool, R</au><au>Chowdri, N A</au><au>Rashid, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study</atitle><jtitle>Indian journal of cancer</jtitle><addtitle>Indian J Cancer</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>53</volume><issue>4</issue><spage>524</spage><pages>524-</pages><issn>0019-509X</issn><eissn>1998-4774</eissn><abstract>Glutathione S.transferases. (GSTs) are known to play a pivotal role in the detoxification of potential carcinogens, and their gene variation may alter susceptibility to colorectal cancer. (CRC). The aim of the study was to evaluate the genetic association of GSTM1 and GSTT1 gene deletion/null polymorphism with disease susceptibility and risk development in CRC patients of ethnic Kashmiri population.
Genotype frequencies of GSTM1 and GSTT1 gene deletion/null polymorphism were compared between 160 CRC patients and 200 healthy controls using polymerase chain reaction multiplex.
The frequency of GSTM1-null was found to be 76.2% in cases and 81.5% in controls and odds ratio. (OR) = 1.37 (95% confidence interval. [CI]: 0.82-2.28). Likewise, the GSTT1-null genotype was found in 75.5% of cases and 77.5% of controls and the OR = 1.14 (95% CI: 0.76-1.8). The overall association between the GSTM1-null and GSTT1-null polymorphism and the CRC cases was found to be insignificant (P < 0.05). However, individuals with double-null genotype (GSTM1-/GSTT1-) were found to have 3.5-fold increased risk for the development of CRC. Further, the risk genotype (null) of GSTT1 was found to be associated with tumor grade (P = 0.001) and GSTM1 (null) genotype was significantly associated with smoking status (P = 0.004), when compared to the (present) genotype in CRC cases.
Our results suggest that GSTM1 and GSTT1 gene deletion/null gene polymorphisms are not a key modulators of the risk of developing CRC in Kashmiri population.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><pmid>28485343</pmid><doi>10.4103/ijc.IJC_17_17</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-509X |
| ispartof | Indian journal of cancer, 2016-10, Vol.53 (4), p.524 |
| issn | 0019-509X 1998-4774 |
| language | eng |
| recordid | cdi_proquest_journals_1903885667 |
| source | MEDLINE; Medknow Open Access Journals; Bioline International; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Amino acids Asian Continental Ancestry Group - genetics Biochemistry Case-Control Studies Colorectal cancer Colorectal Neoplasms - genetics Deoxyribonucleic acid Diabetes DNA Enzymes Female Genes Genetic Predisposition to Disease Genetic testing Genotype Genotype & phenotype Glutathione Transferase - genetics Humans Immunology India Male Metabolism Metabolites Middle Aged Odds Ratio Patients Polymorphism, Single Nucleotide Population Quality control Sample size Studies |
| title | Evaluation of deletion polymorphisms of glutathione S-transferase genes and colorectal cancer risk in ethnic Kashmiri population: A case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T07%3A27%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20deletion%20polymorphisms%20of%20glutathione%20S-transferase%20genes%20and%20colorectal%20cancer%20risk%20in%20ethnic%20Kashmiri%20population:%20A%20case-control%20study&rft.jtitle=Indian%20journal%20of%20cancer&rft.au=Nissar,%20S&rft.date=2016-10-01&rft.volume=53&rft.issue=4&rft.spage=524&rft.pages=524-&rft.issn=0019-509X&rft.eissn=1998-4774&rft_id=info:doi/10.4103/ijc.IJC_17_17&rft_dat=%3Cproquest_cross%3E1903885667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1903885667&rft_id=info:pmid/28485343&rfr_iscdi=true |