Ignavine: a novel allosteric modulator of the [mu] opioid receptor

Processed Aconiti tuber (PAT) is used to treat pain associated with various disorders. Although it has been demonstrated that the κ opioid receptor (KOR) signaling pathway is a mediator of the analgesic effect of PAT, active components affecting opioid signaling have not yet been identified. In this...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6, p.31748
Hauptverfasser:	Ohbuchi, Katsuya, Miyagi, Chika, Suzuki, Yasuyuki, Mizuhara, Yasuharu, Mizuno, Keita, Omiya, Yuji, Yamamoto, Masahiro, Warabi, Eiji, Sudo, Yuka, Yokoyama, Akinobu, Miyano, Kanako, Hirokawa, Takatsugu, Uezono, Yasuhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Allosteric properties Analgesics Cell lines Cyclic AMP Endomorphin-1 Enkephalins Internalization Morphine Narcotics Opioid receptors (type mu) Pain Pharmacokinetics Signal transduction Simulation analysis
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