Bifunctional Brønsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective C[alpha]-Alkylation of [beta]-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones

The catalytic asymmetric synthesis of both [alpha]-substituted and [alpha],[alpha]-disubstituted (quaternary) [beta]-tetralones through direct [alpha]-functionalization of the corresponding [beta]-tetralone precursor remains elusive. A designed Brønsted base-squaramide bifunctional catalyst promotes...

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Veröffentlicht in:	Angewandte Chemie 2017-02, Vol.129 (8), p.2091
Hauptverfasser:	Urruzuno, Iñaki, Mugica, Odei, Oiarbide, Mikel, Palomo, Claudio
Format:	Artikel
Sprache:	ger
Schlagworte:	Adducts Alkylation Asymmetric synthesis Carbon Catalysts Chemical synthesis Chemistry Enantiomers
Online-Zugang:	Volltext
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