Chronic toxicity of arsenic during Rhinella arenarum embryonic and larval development: Potential biomarkers of oxidative stress and antioxidant response
The Argentinean autochthonous toad Rhinella arenarum was selected to study the chronic toxicity of arsenic (As) and the biochemical responses elicited by exposure to As in water during embryonic and larval development. Significant decreases in the total reactive antioxidant potential and in catalase...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2017-06, Vol.36 (6), p.1614-1621 |
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| creator | Mardirosian, Mariana Noelia Lascano, Cecilia Inés Bongiovanni, Guillermina Azucena Venturino, Andrés |
| description | The Argentinean autochthonous toad Rhinella arenarum was selected to study the chronic toxicity of arsenic (As) and the biochemical responses elicited by exposure to As in water during embryonic and larval development. Significant decreases in the total reactive antioxidant potential and in catalase activity were observed in individuals exposed chronically to sublethal concentrations of As, which is indicative of an oxidative stress situation. However, an antioxidant response was elicited during chronic exposure to As, as evidenced by the increase in endogenous reduced glutathione content and glutathione‐related enzymatic activities such as glutathione S‐transferase (GST) and glutathione reductase. This protective response might prevent a deeper decline in the antioxidant system and further oxidative damage. Alternatively, it might be linked to As conjugation with reduced glutathione for its excretion. Considering the sustained increase in GST activity and the decrease in the total antioxidant reactive potential observed, the authors propose them as good candidates to be used as biomarkers during As exposure. Interestingly, glutathione reductase activity was inhibited at a very low concentration of As considered safe for aquatic life. Environ Toxicol Chem 2017;36:1614–1621. © 2016 SETAC |
| doi_str_mv | 10.1002/etc.3693 |
| format | Article |
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Significant decreases in the total reactive antioxidant potential and in catalase activity were observed in individuals exposed chronically to sublethal concentrations of As, which is indicative of an oxidative stress situation. However, an antioxidant response was elicited during chronic exposure to As, as evidenced by the increase in endogenous reduced glutathione content and glutathione‐related enzymatic activities such as glutathione S‐transferase (GST) and glutathione reductase. This protective response might prevent a deeper decline in the antioxidant system and further oxidative damage. Alternatively, it might be linked to As conjugation with reduced glutathione for its excretion. Considering the sustained increase in GST activity and the decrease in the total antioxidant reactive potential observed, the authors propose them as good candidates to be used as biomarkers during As exposure. Interestingly, glutathione reductase activity was inhibited at a very low concentration of As considered safe for aquatic life. 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Significant decreases in the total reactive antioxidant potential and in catalase activity were observed in individuals exposed chronically to sublethal concentrations of As, which is indicative of an oxidative stress situation. However, an antioxidant response was elicited during chronic exposure to As, as evidenced by the increase in endogenous reduced glutathione content and glutathione‐related enzymatic activities such as glutathione S‐transferase (GST) and glutathione reductase. This protective response might prevent a deeper decline in the antioxidant system and further oxidative damage. Alternatively, it might be linked to As conjugation with reduced glutathione for its excretion. Considering the sustained increase in GST activity and the decrease in the total antioxidant reactive potential observed, the authors propose them as good candidates to be used as biomarkers during As exposure. Interestingly, glutathione reductase activity was inhibited at a very low concentration of As considered safe for aquatic life. Environ Toxicol Chem 2017;36:1614–1621. © 2016 SETAC</description><subject>Amphibian</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aquatic organisms</subject><subject>Aquatic toxicology</subject><subject>Arsenic</subject><subject>Arsenic - administration & dosage</subject><subject>Arsenic - toxicity</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bufo arenarum - embryology</subject><subject>Bufo arenarum - growth & development</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>Chronic exposure</subject><subject>Chronic toxicity</subject><subject>Conjugation</subject><subject>Damage prevention</subject><subject>Detoxification</subject><subject>Drug Administration Schedule</subject><subject>Embryogenesis</subject><subject>Environmental Pollutants - toxicity</subject><subject>Enzymatic activity</subject><subject>Excretion</subject><subject>Exposure</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Glutathione reductase</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione S‐transferase</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - metabolism</subject><subject>Larva - drug effects</subject><subject>Larval development</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Stress response</subject><subject>Total reactive antioxidant potential</subject><subject>Toxicity</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMotlbBJ5CAGzdTk7lkJu6keIOCIroeMpMzNnUmqUmm2jfxcU0vunN14M-X75D8CJ1SMqaExJfg63HCeLKHhjTL4qhgtNhHQ5InJMpjVgzQkXNzQijjnB-iQZwXGc8YHaLvycwarWrszZeqlV9h02BhHawz2Vul3_DzTGloWxFy0ML2HYausqvNNaElboVdihZLWEJrFh1of4WfjA9ThbhSphP2Haxbq8MWKbxaAnbegnMbgQjk5kB7HMKF0Q6O0UEjWgcnuzlCr7c3L5P7aPp49zC5nkZ1UrAkagRUkqWUx5LxmLGGJnUDlSApgYQ3PA8JBU6llEVFsizLaZMXIuW5EBWTNBmh8613Yc1HD86Xc9NbHVaWlJOY0jTNWaAutlRtjXMWmnJhVXjWqqSkXFdQhgrKdQUBPdsJ-6oD-Qf-_nkAoi3wqVpY_SsqA7MR_gAtSpP7</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Mardirosian, Mariana Noelia</creator><creator>Lascano, Cecilia Inés</creator><creator>Bongiovanni, Guillermina Azucena</creator><creator>Venturino, Andrés</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>201706</creationdate><title>Chronic toxicity of arsenic during Rhinella arenarum embryonic and larval development: Potential biomarkers of oxidative stress and antioxidant response</title><author>Mardirosian, Mariana Noelia ; Lascano, Cecilia Inés ; Bongiovanni, Guillermina Azucena ; Venturino, Andrés</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3863-faebd64192d69266f13cfeba040e39f976f11e91ddd8b055571f78a497aab6d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amphibian</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Aquatic organisms</topic><topic>Aquatic toxicology</topic><topic>Arsenic</topic><topic>Arsenic - administration & dosage</topic><topic>Arsenic - toxicity</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bufo arenarum - embryology</topic><topic>Bufo arenarum - growth & development</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>Chronic exposure</topic><topic>Chronic toxicity</topic><topic>Conjugation</topic><topic>Damage prevention</topic><topic>Detoxification</topic><topic>Drug Administration Schedule</topic><topic>Embryogenesis</topic><topic>Environmental Pollutants - toxicity</topic><topic>Enzymatic activity</topic><topic>Excretion</topic><topic>Exposure</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Glutathione reductase</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione S‐transferase</topic><topic>Glutathione transferase</topic><topic>Glutathione Transferase - metabolism</topic><topic>Larva - drug effects</topic><topic>Larval development</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Stress response</topic><topic>Total reactive antioxidant potential</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mardirosian, Mariana Noelia</creatorcontrib><creatorcontrib>Lascano, Cecilia Inés</creatorcontrib><creatorcontrib>Bongiovanni, Guillermina Azucena</creatorcontrib><creatorcontrib>Venturino, Andrés</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mardirosian, Mariana Noelia</au><au>Lascano, Cecilia Inés</au><au>Bongiovanni, Guillermina Azucena</au><au>Venturino, Andrés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic toxicity of arsenic during Rhinella arenarum embryonic and larval development: Potential biomarkers of oxidative stress and antioxidant response</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environ Toxicol Chem</addtitle><date>2017-06</date><risdate>2017</risdate><volume>36</volume><issue>6</issue><spage>1614</spage><epage>1621</epage><pages>1614-1621</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><abstract>The Argentinean autochthonous toad Rhinella arenarum was selected to study the chronic toxicity of arsenic (As) and the biochemical responses elicited by exposure to As in water during embryonic and larval development. Significant decreases in the total reactive antioxidant potential and in catalase activity were observed in individuals exposed chronically to sublethal concentrations of As, which is indicative of an oxidative stress situation. However, an antioxidant response was elicited during chronic exposure to As, as evidenced by the increase in endogenous reduced glutathione content and glutathione‐related enzymatic activities such as glutathione S‐transferase (GST) and glutathione reductase. This protective response might prevent a deeper decline in the antioxidant system and further oxidative damage. Alternatively, it might be linked to As conjugation with reduced glutathione for its excretion. Considering the sustained increase in GST activity and the decrease in the total antioxidant reactive potential observed, the authors propose them as good candidates to be used as biomarkers during As exposure. Interestingly, glutathione reductase activity was inhibited at a very low concentration of As considered safe for aquatic life. Environ Toxicol Chem 2017;36:1614–1621. © 2016 SETAC</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27859561</pmid><doi>10.1002/etc.3693</doi><tpages>8</tpages></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2017-06, Vol.36 (6), p.1614-1621 |
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| subjects | Amphibian Animals Antioxidants Antioxidants - metabolism Aquatic organisms Aquatic toxicology Arsenic Arsenic - administration & dosage Arsenic - toxicity Biomarkers Biomarkers - blood Bufo arenarum - embryology Bufo arenarum - growth & development Catalase Catalase - metabolism Chronic exposure Chronic toxicity Conjugation Damage prevention Detoxification Drug Administration Schedule Embryogenesis Environmental Pollutants - toxicity Enzymatic activity Excretion Exposure Glutathione Glutathione - metabolism Glutathione reductase Glutathione Reductase - metabolism Glutathione S‐transferase Glutathione transferase Glutathione Transferase - metabolism Larva - drug effects Larval development Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Stress response Total reactive antioxidant potential Toxicity |
| title | Chronic toxicity of arsenic during Rhinella arenarum embryonic and larval development: Potential biomarkers of oxidative stress and antioxidant response |
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