A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets

Microfluidic perfusion systems (MPS) are well suited to perform multiparametric measurements with small amounts of tissue to function as an Organ on Chip device (OOC). Such microphysiolgical characterization is particularly valuable in research on the stimulus-secretion-coupling of pancreatic islets...

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Veröffentlicht in:	Biomedical microdevices 2017-09, Vol.19 (3), p.47, Article 47
Hauptverfasser:	Schulze, Torben, Mattern, Kai, Früh, Eike, Hecht, Lars, Rustenbeck, Ingo, Dietzel, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beads Biochips Biological and Medical Physics Biomedical engineering Biomedical Engineering and Bioengineering Biophysics Borosilicate glass Calcium Engineering Engineering Fluid Dynamics Equipment Design Exchanging Flow velocity Fluid mechanics Fluorescence Glass Imaging, Three-Dimensional Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Kinetics Lab-On-A-Chip Devices Laser ablation Latex Latex beads Mechanical stimuli Mice Microchannels Microfluidics Microspheres NAD Nanotechnology Organs Oxygen consumption Pancreas Perfusion Perfusion - instrumentation Rapid prototyping Retention Secretion Shear stress Well design
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