AB0309 Value of The Clinical Meetings for An Accurate Biological Therapy Assessment in Rheumatic Diseases. The Experience of The Biological Therapy Assessment Committee at A Tertiary Hospital

BackgroundGiven the increasing use of biological therapies in rheumatologic diseases and the importance of their secondary effects, it has been promoted clinical Meetings for an accurate Biological Therapy Assessment (BTAM). In the BTAM rheumatologists consider the need to initiating biological therapy, changes in biological therapeutic targets, sustained biological treatment or their suspension.ObjectivesTo assess the BTAM effectiveness in patients with rheumatic diseases in a Rheumatology Department in a tertiary-level hospital.MethodsProspective study including all consultations to BTAM between 2013 and 2015 in the Rheumatology Department of La Fe Hospital. Consultations were classified as: “therapeutic target modification”, “route of administration modification”, “dose treatment modification”, “new biological treatment”, “treatment continuation” and “treatment suspension”. In order to evaluate disease activity, we used DAS28, BASDAI, serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Biostatistical analysis was performed using R software 3.2.3.ResultsWe included 1683 BTAM consultations, corresponding to 517 patients with rheumatic diseases with a mean age of 39.94±14.88 and 13.37±8.75 years of disease progression. 51.6% of patients were rheumatoid arthritis, 27.9% spondyloarthritis, 15.3% psoriatic arthritis and 5.2% other diagnosis. 116 patients received a prior biological treatment. Disease activity evaluation of the 1683 BTAM consultations for the main categories is shown in the table.Therapeutic target modificationDose treatment modificationNew biological treatmentTreatment continuationn (%)n (%)n (%)n (%)TOTAL88 (5.2%)79 (4.7%)52 (3.1%)1405 (83.5%)DAS284.32±1.682.74±1.394.78±0.972.8±1.23BASDAI6.3±1.713.03±1.896.74±1.284.29±2.36ESR26.12±28.1317.47±18.4317.26±11.9913.79±12.54CRP10.21±15.234.15±4.418.22±9.043.88±6.41Biostatistic analysis shows significant differences in Das28, BASDAI, CRP and ESR values between BTAM consultations for initiating new treatment or modify therapeutic target, and treatment continuation consultations (P