THU0256 Complement C3 Exacerbates TLR7-Mediated Skin Inflammation but Not Systemic Autoimmunity

BackgroundShort–term topical application of a Toll-like receptor 7 (TLR7) agonist, Imiquimod (IMQ), is a widely used murine model of psoriasis. Recently long–term epicutaneous application (4–8 weeks) of IMQ has been shown to elicit lupus-like manifestations. Importantly the topical application of IM...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75 (Suppl 2), p.280-281
Hauptverfasser:	Giacomassi, C., Ling, G.S., Buang, N., Strid, J., Botto, M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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