AB0723 The Clinical Assessment of Anti-Cyclic Citrullinated Peptide Antibodies in Psoriatic Arthritis

BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory disease in the spondyloarthropathy group with the history of psoriasis. Although some PsA findings are similar to rheumatoid arthritis (RA), RF negativity, some radiological and clinical findings are different in PsA. There is no spesific laboratory examination for diagnosis of PsA. On the other hand, anti-CCP antibody positivity is a spesific finding for the diagnosis of RA.ObjectivesWe aimed in this study to analyse the frequency of anti-CCP positivity in PsA and the assciaton with clinical and radiological findings.MethodsThe study group is consisted of 100 PsA patients, who fulfilled the CASPAR cirteria for PsA and 100 healthy controls (HC). We filled a form for all patients, which included clinical and laboratory findings of patients. We analyzed anti-CCP antibody with microELISA in the sera of patients.ResultsIn our study, the anti-CCP positivity (40,9±63,5 IU/ml) was detected in 15% of PsA group and 4% of healthy controls. The difference was statistically significant (p=0,014; OR=4.24, 95% CI=1.35–13.25).Nine out of 15 anti-CCP positive patients were female, the remaining 6 were male. Thirteen patients (86,7%) had peripheral arthritis, 1 patient (6,7%)had sacroiliitis, 1 patient (6,7%) had peripheral arthritis and sacroiliitis. 42,8% of PsA patients with peripheral arthritis had asymetric olygoarthritis (6/14), 28,5% had monoarthritis (4/14) and 28,5% had symetric polyarthritis (4/14). Anti-CCP antibody positivity had no effect on the involvement of peripheral arthritis. Sacroiliitis and dactilitis were more frequent in the anti-CCP negative group. No patient with dactylitis had anti-CCP positivity (p=0.005). While, 43,5% of RF positive patients were detected anti-CCP positivity, 6,5% of RF negative patients were detected anti-CCP positivity (p=0,000).Table 1.The frequency of disease findings in anti-CCP positive and negative groupsCCP(−)CCP(+)pOR95% CI(n=85)(n=15)Sex: Female / Male64.7% / 35.3%60% / 40%0.0712.750.889–8.47Increased ESH32.9%46.7%0.1781.780.587–5.4Increased CRP34.1%40%0.7711.290.417–3.97RF >2015.3%66.7%0.0011.083.25–37.7Deformity21.2%26.7%0.7361.350.385–4.76Sacroiliitis21.2%13.3%0.7291.750.361–8.15Radiographic changes15%0%0.2070.8280.752–0.911Anti-TNF treatment31.8%26.7%0.0770.780.228–2.67PSARC responce84.7%86.7%10.8520.172–4.23ConclusionsOur data reveals that anti-CCP positivity is more frequent in PsA compared to HC. We found no statisticall association between anti-CCP p