AB0677 Comparative Characteristics of Radiographic and Non-Radiographic Axial Spondyloarthritis (NR-AXSPA) Based on Data from 12 Month Follow Up of Corsar Cohort

AB0677 Comparative Characteristics of Radiographic and Non-Radiographic Axial Spondyloarthritis (NR-AXSPA) Based on Data from 12 Month Follow Up of Corsar Cohort

BackgroundClinical similarity of nr-axSpA and ankylosing spondylitis (AS) has been well established, but whether nr-axSpA is an initial stage of AS, or these two subtypes are nosologically self-determined entities is still being debated.ObjectivesTo study the evolution of early axial spondyloarthrit...

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Veröffentlicht in:Annals of the rheumatic diseases 2016-06, Vol.75 (Suppl 2), p.1136
Hauptverfasser: Dubinina, T., Rumyantseva, D., Rumyantseva, O., Demina, A., Gubar, E., Erdes, S.
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container_title Annals of the rheumatic diseases
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creator Dubinina, T.
Rumyantseva, D.
Rumyantseva, O.
Demina, A.
Gubar, E.
Erdes, S.
description BackgroundClinical similarity of nr-axSpA and ankylosing spondylitis (AS) has been well established, but whether nr-axSpA is an initial stage of AS, or these two subtypes are nosologically self-determined entities is still being debated.ObjectivesTo study the evolution of early axial spondyloarthritis (axSpA) in the Moscow axSpA cohort of patients (pts) - CoRSaR (Russian acronym from CohoRt of early axSpA pts).MethodsCurrently the CoRSaR cohort includes 94 axSpA pts with
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Evaluation of all pts at inclusion (Mo0) and FUP (Mo12) visits was similar and included: medical case history, clinical examination, X-ray of pelvis (and other segments of the back bone and joints, when necessary) - following ASAS guidelines, MRI of sacroiliac joints. Pts' mean age at Mo0 visit was 27,1±5,5 y., average disease duration - 22,4±15,1 mo, 49 (90,7%) pts were HLA-B27 positive.ResultsPts were grouped into 2 arms to analyze axSpA evolution: Group 1 – nr-axSpA, Group 2 – AS. The table shows pts' baseline and FUP Mo12 visit characteristics. No significant difference has been found between the two groups – radiographic AS and nr-axSpA - in terms of prevalence of arthritis, enthesitis, BASDAI, ASDAS CRP, and BASFI scores. Radiographic sacroiliitis, i.e., AS, has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo FUP.Table 1Mo0 visit (n=54)FUP Mo12 visit (n=54)ASNr-axSpAASNr-axSpApn=31 (57.4%)n=23 (42.6%)n=40 (74.0%)n=14 (26.0%)Gender: m, % / f ,%17 (54.8%) / 14 (45.2%)7 (30.4%) / 16 (69.6%)0.0720 (50.0%) / 20 (50.0%)4 (28.5%) / 10 (71.5%)0.16BASDAI score, Me [25%;75%]3.4 [1.6; 5.1]3.5 [2.0; 4.9]0.831.8 [0.80; 3.65]2.75 [1.2; 3.6]0.57BASFI score, Me [25%;75%]1.2 [0.3; 2.5]1.4 [0.3; 2.5]0.830.65 [0; 2.05]0.35 [0.1; 1.3]0.77ASDAS-CRP score, Me [25%;75%]2.5 [1.4; 3.1]1.8 [1.3; 3.1]0.41.35 [1.1; 2.05]1.3 [1.0; 2.1]0.78CRP, mg/L, Me [25%;75%]4.3 [1.0; 20.0]4.8 [0.6; 9.7]1.02.3 [0.85; 10.1]2.5 [0.8; 4.8]0.78ESR, mm/h, Me [25%;75%]13.0 [5.0; 24.0]8.0 [5.0; 14.0]0.47.5 [5.0; 21.0]6.5 [5.0; 8.0]0.38MASES score, Me [25%;75%]1.0 [0.0; 2.0]1.0 [0; 3.0]0.810 [0; 1.0]0 [0; 0]1.0SJC, Me [25%; 75%]0.0 [0; 0]0.0 [0; 0]0.288840 [0; 0]0 [0; 0]0.00000ConclusionsNo clinical differences between radiologically confirmed axSpA (i.e., AS) and nr-axSpA were established. AS has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo.Disclosure of InterestNone declared</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2016-eular.3399</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><ispartof>Annals of the rheumatic diseases, 2016-06, Vol.75 (Suppl 2), p.1136</ispartof><rights>2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2016 (c) 2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/75/Suppl_2/1136.2.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/75/Suppl_2/1136.2.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,23571,27924,27925,77600,77631</link.rule.ids></links><search><creatorcontrib>Dubinina, T.</creatorcontrib><creatorcontrib>Rumyantseva, D.</creatorcontrib><creatorcontrib>Rumyantseva, O.</creatorcontrib><creatorcontrib>Demina, A.</creatorcontrib><creatorcontrib>Gubar, E.</creatorcontrib><creatorcontrib>Erdes, S.</creatorcontrib><title>AB0677 Comparative Characteristics of Radiographic and Non-Radiographic Axial Spondyloarthritis (NR-AXSPA) Based on Data from 12 Month Follow Up of Corsar Cohort</title><title>Annals of the rheumatic diseases</title><description>BackgroundClinical similarity of nr-axSpA and ankylosing spondylitis (AS) has been well established, but whether nr-axSpA is an initial stage of AS, or these two subtypes are nosologically self-determined entities is still being debated.ObjectivesTo study the evolution of early axial spondyloarthritis (axSpA) in the Moscow axSpA cohort of patients (pts) - CoRSaR (Russian acronym from CohoRt of early axSpA pts).MethodsCurrently the CoRSaR cohort includes 94 axSpA pts with &lt;5 years of inflammatory back pain duration (ASAS 2009y.criteria). 54 out of them with at least 12 months (mo) follow up pts (FUP) were included into preliminary analysis of axSpA evolution study. Evaluation of all pts at inclusion (Mo0) and FUP (Mo12) visits was similar and included: medical case history, clinical examination, X-ray of pelvis (and other segments of the back bone and joints, when necessary) - following ASAS guidelines, MRI of sacroiliac joints. Pts' mean age at Mo0 visit was 27,1±5,5 y., average disease duration - 22,4±15,1 mo, 49 (90,7%) pts were HLA-B27 positive.ResultsPts were grouped into 2 arms to analyze axSpA evolution: Group 1 – nr-axSpA, Group 2 – AS. The table shows pts' baseline and FUP Mo12 visit characteristics. No significant difference has been found between the two groups – radiographic AS and nr-axSpA - in terms of prevalence of arthritis, enthesitis, BASDAI, ASDAS CRP, and BASFI scores. Radiographic sacroiliitis, i.e., AS, has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo FUP.Table 1Mo0 visit (n=54)FUP Mo12 visit (n=54)ASNr-axSpAASNr-axSpApn=31 (57.4%)n=23 (42.6%)n=40 (74.0%)n=14 (26.0%)Gender: m, % / f ,%17 (54.8%) / 14 (45.2%)7 (30.4%) / 16 (69.6%)0.0720 (50.0%) / 20 (50.0%)4 (28.5%) / 10 (71.5%)0.16BASDAI score, Me [25%;75%]3.4 [1.6; 5.1]3.5 [2.0; 4.9]0.831.8 [0.80; 3.65]2.75 [1.2; 3.6]0.57BASFI score, Me [25%;75%]1.2 [0.3; 2.5]1.4 [0.3; 2.5]0.830.65 [0; 2.05]0.35 [0.1; 1.3]0.77ASDAS-CRP score, Me [25%;75%]2.5 [1.4; 3.1]1.8 [1.3; 3.1]0.41.35 [1.1; 2.05]1.3 [1.0; 2.1]0.78CRP, mg/L, Me [25%;75%]4.3 [1.0; 20.0]4.8 [0.6; 9.7]1.02.3 [0.85; 10.1]2.5 [0.8; 4.8]0.78ESR, mm/h, Me [25%;75%]13.0 [5.0; 24.0]8.0 [5.0; 14.0]0.47.5 [5.0; 21.0]6.5 [5.0; 8.0]0.38MASES score, Me [25%;75%]1.0 [0.0; 2.0]1.0 [0; 3.0]0.810 [0; 1.0]0 [0; 0]1.0SJC, Me [25%; 75%]0.0 [0; 0]0.0 [0; 0]0.288840 [0; 0]0 [0; 0]0.00000ConclusionsNo clinical differences between radiologically confirmed axSpA (i.e., AS) and nr-axSpA were established. AS has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo.Disclosure of InterestNone declared</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkUlOxDAQRS0EEs1wB0tsYBGw49hJliGMUtMgBomdVUkc4lYSB9vNsGPDSbgZJyENLGD1q76-6kv1ENqhZJ9SJg6g722jFl2lXRASKgK1aMHuM5amK2hCI5GMtiCraEIIYUGUingdbTg3H1eS0GSCPrJDIuL48-09N90AFrx-Ujhvxqn0ymrndemwqfE1VNo8WBgaXWLoKzwzffDPzF40tPhmMH312hqwvrHaa4d3Z9dBdn9zle3hQ3CqwqbHR-AB19Z0mIb4wvS-wSembc0zvhuWbbmxDuwojbF-C63V0Dq1_aub6Pbk-DY_C6aXp-d5Ng2KmJMAijKsC8UTRsqaxowJEqrxA1Uc1yLkAihJFVeKFSqiCadRRJWoozSpoeCcV2wT7fycHax5XCjn5dwsbD82SpoSmiQ05WRMiZ9U0c3lYHUH9lVSIpc85B8ecslDfvOQSx7sC9KvhPI</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Dubinina, T.</creator><creator>Rumyantseva, D.</creator><creator>Rumyantseva, O.</creator><creator>Demina, A.</creator><creator>Gubar, E.</creator><creator>Erdes, S.</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201606</creationdate><title>AB0677 Comparative Characteristics of Radiographic and Non-Radiographic Axial Spondyloarthritis (NR-AXSPA) Based on Data from 12 Month Follow Up of Corsar Cohort</title><author>Dubinina, T. ; Rumyantseva, D. ; Rumyantseva, O. ; Demina, A. ; Gubar, E. ; Erdes, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b750-abc2fbe5830cf1733602e468d77f6256a109e5ee3be41851441e6f498fab555d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubinina, T.</creatorcontrib><creatorcontrib>Rumyantseva, D.</creatorcontrib><creatorcontrib>Rumyantseva, O.</creatorcontrib><creatorcontrib>Demina, A.</creatorcontrib><creatorcontrib>Gubar, E.</creatorcontrib><creatorcontrib>Erdes, S.</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubinina, T.</au><au>Rumyantseva, D.</au><au>Rumyantseva, O.</au><au>Demina, A.</au><au>Gubar, E.</au><au>Erdes, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AB0677 Comparative Characteristics of Radiographic and Non-Radiographic Axial Spondyloarthritis (NR-AXSPA) Based on Data from 12 Month Follow Up of Corsar Cohort</atitle><jtitle>Annals of the rheumatic diseases</jtitle><date>2016-06</date><risdate>2016</risdate><volume>75</volume><issue>Suppl 2</issue><spage>1136</spage><pages>1136-</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>BackgroundClinical similarity of nr-axSpA and ankylosing spondylitis (AS) has been well established, but whether nr-axSpA is an initial stage of AS, or these two subtypes are nosologically self-determined entities is still being debated.ObjectivesTo study the evolution of early axial spondyloarthritis (axSpA) in the Moscow axSpA cohort of patients (pts) - CoRSaR (Russian acronym from CohoRt of early axSpA pts).MethodsCurrently the CoRSaR cohort includes 94 axSpA pts with &lt;5 years of inflammatory back pain duration (ASAS 2009y.criteria). 54 out of them with at least 12 months (mo) follow up pts (FUP) were included into preliminary analysis of axSpA evolution study. Evaluation of all pts at inclusion (Mo0) and FUP (Mo12) visits was similar and included: medical case history, clinical examination, X-ray of pelvis (and other segments of the back bone and joints, when necessary) - following ASAS guidelines, MRI of sacroiliac joints. Pts' mean age at Mo0 visit was 27,1±5,5 y., average disease duration - 22,4±15,1 mo, 49 (90,7%) pts were HLA-B27 positive.ResultsPts were grouped into 2 arms to analyze axSpA evolution: Group 1 – nr-axSpA, Group 2 – AS. The table shows pts' baseline and FUP Mo12 visit characteristics. No significant difference has been found between the two groups – radiographic AS and nr-axSpA - in terms of prevalence of arthritis, enthesitis, BASDAI, ASDAS CRP, and BASFI scores. Radiographic sacroiliitis, i.e., AS, has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo FUP.Table 1Mo0 visit (n=54)FUP Mo12 visit (n=54)ASNr-axSpAASNr-axSpApn=31 (57.4%)n=23 (42.6%)n=40 (74.0%)n=14 (26.0%)Gender: m, % / f ,%17 (54.8%) / 14 (45.2%)7 (30.4%) / 16 (69.6%)0.0720 (50.0%) / 20 (50.0%)4 (28.5%) / 10 (71.5%)0.16BASDAI score, Me [25%;75%]3.4 [1.6; 5.1]3.5 [2.0; 4.9]0.831.8 [0.80; 3.65]2.75 [1.2; 3.6]0.57BASFI score, Me [25%;75%]1.2 [0.3; 2.5]1.4 [0.3; 2.5]0.830.65 [0; 2.05]0.35 [0.1; 1.3]0.77ASDAS-CRP score, Me [25%;75%]2.5 [1.4; 3.1]1.8 [1.3; 3.1]0.41.35 [1.1; 2.05]1.3 [1.0; 2.1]0.78CRP, mg/L, Me [25%;75%]4.3 [1.0; 20.0]4.8 [0.6; 9.7]1.02.3 [0.85; 10.1]2.5 [0.8; 4.8]0.78ESR, mm/h, Me [25%;75%]13.0 [5.0; 24.0]8.0 [5.0; 14.0]0.47.5 [5.0; 21.0]6.5 [5.0; 8.0]0.38MASES score, Me [25%;75%]1.0 [0.0; 2.0]1.0 [0; 3.0]0.810 [0; 1.0]0 [0; 0]1.0SJC, Me [25%; 75%]0.0 [0; 0]0.0 [0; 0]0.288840 [0; 0]0 [0; 0]0.00000ConclusionsNo clinical differences between radiologically confirmed axSpA (i.e., AS) and nr-axSpA were established. AS has developed in 9 (39%) out of 23 nr-axSpA pts during 12 Mo.Disclosure of InterestNone declared</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/annrheumdis-2016-eular.3399</doi></addata></record>
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