AB0770 Serum Calcidiol, Dual-Energy X-Ray Absorptiometry and Lung Respiratory Tests in Patients with Interstitial Lung Diseases

BackgroundVitamin D plays an essential paper in the regulation of the bone metabolism. Its role in the modulation of the autoimmune system is better known every day as well as its involvement in the pathogenesis of the autoimmune diseases. Some studies have shown a possible implication of the vitamin D in the development of lung diseases, as the interstitial lung diseases (ILD) through the inhibition of the fibroblasts' profibrotic phenotype. Likewise, it's been described a possible association between serum calcidiol levels and a decreased pulmonary function.ObjectivesAnalyze the prevalence of vitamin D insufficiency. Evaluate a possible relationship between calcidiol levels and lung respiratory tests. Asses the prevalence of low bone mineral density (BMD) and its correlation with risk factors.MethodsRetrospective study of a cohort of patients with ILD referred from the pulmonary consultation. We analyzed demographic and analytics aspects, dual-energy x-ray absorptiometry (DXA), spinal column radiographies, and lung respiratory tests. The statistical study was performed with SPSS.Results44 patients were recruited, 68% women with median age 66 years. 45.5% presented an idiopathic ILD (Usual Interstitial Pneumonia (UIP), Nonspecific IP and Cryptogenic Organizing Pneumonia) and 40.1% sarcoidosis. The 20% left was composed by patients with ANCA-Vasculitis (2), Extrinsic Allergic Alveolitis (6) and ILD related to connective tissue diseases (3 Rheumatoid Arthritis). 79.5% had received corticosteroids with a median dose of 5 grams.The prevalence of vitamin D insufficiency (