AB0468 Caracteristics of Renal Involvement in Patients with Primary Sjögren's Syndrome

BackgroundRenal involvement is one of the most common manifestations of primary Sjögren's syndrome (pSS) and has no specific symptoms.Objectives- Identify the clinical and biological characteristics of patients with renal involvement in pSS.- Identify the immunological profile of these patients.- Specify the adequate treatment.MethodsFourty five patients with pSS admitted inCharles Nicolleuniversity Hospital from 2005 to 2015 were enrolled. All the patients met the validated European-American co-criteria of 2002 for pSS. No patients with secondary SS were included.ResultsFourty five patients were enrolled in our study. Nine of them had renal involvement: eight women and 1 man. The mean age was 44,5 years. Time from onset to diagnosis was about 2,33 years. Concerning the kidney damage, 4 of the patients developed renal tubular acidosis (RTA), 3 of them developed others tubulo-interstitial disorders and 2 were diagnosed with glomerular disorder withhigh proteinuria. One of the nine patients had diabetis insipidus. Laboratory examinations showed 3 cases of hyperchloremia and 6 cases of hypokaliemia. One patient had hypokaliemic paralysis. Six patients had creatinincleranceunder 50 ml/mn.All patients received symptomatic treatment. Seven patients were treated with corticosteroids and 3 patients received hydroxylchloroquine.ConclusionsPatients with pSS commonly present with renal impairment.Tubular disorders are the main renal involvementespecially RTA. Glomerular lesions might be predominant. Morbidity of chronic renal failure might account for a certain proportion of pSS. Corticosteroids therapy might improve the prognosis.ReferencesVitali C, Tavoni A, Sciuto M, Maccheroni M, Moriconi L, Bombardieri S. Renal involvement in primary Sjögren's syndrome: a retrospective-prospective study. Scand J Rheumatol 1991;20:132–6.Bossini N, Savoldi S, Franceschini F, et al. Clinical and morphological features of kidney involvement in primary Sjogren's syndrome.Nephrol Dial Transplant 2001;16:2328–36Rayadurg J, Koch AE. Renal insufficiency from interstitial nephritis in primary Sjögren's syndrome. J Rheumatol 1990;17:1714–8.Viergever PP, Swaak TJ. Renal tubular dysfunction in primary Sjögren's syndrome: clinical studies in 27 patients. ClinRheumatol 1991;10:23–7.Disclosure of InterestNone declared