FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis

BackgroundSpleen Tyrosine Kinase (SYK) mediates signaling in a range of hematopoietic cells involved in the initiation and progression of RA including B cells, monocytes, macrophages, dendritic cells, and osteoclasts. There is strong preclinical validation for SYK as a therapeutic target for RA base...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75 (Suppl 2), p.443-444
Hauptverfasser:	Di Paolo, J., Blomgren, P., Dolton, M., Jones, R., Kropf, J., Lee, T., Mitchell, S., Murray, B., Suekawa-Pirrone, K., Wise, S., Xu, J., Zhao, Z., Currie, K.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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