SAT0184 Signal Transducer and Activator of Transcription 3 (STAT3) Integrates Several Profibrotic Pathways in Systemic Sclerosis

BackgroundSignal transducer and activator of transcription 3 (STAT3) is a transcription factor that is regulated by phosphorylation of key tyrosine residues. Phosphorylation of STAT3 triggers dimerization, nuclear translocation and transcriptional activation. STAT3 can be phosphorylated by JAK2, SRC...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75 (Suppl 2), p.735
Hauptverfasser:	Chakraborty, D., Šumová, B., Mallano, T., Chen, C.-W., Ramming, A., Distler, O., Schett, G., Distler, J.H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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