SAT0186 The Homeoprotein Engrailed-1 Regulates Canonical TGF-[beta] Signaling via Fibroblast Differentiation and Tissue Fibrosis

Background Systemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth factor-β (TGFβ) has been characterized as a key-mediator of fibroblast activation in SSc. However, the intracellular signaling cascades that...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75, p.735
Hauptverfasser:	Mallano, T, Palumbo-Zerr, K, Beyer, C, Dees, C, Huang, J, Wohlfahrt, T, Distler, O, Schett, G, Distler, JH
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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