AB0812 Increased Arterial Stiffness is Associated with Compromised Volumetric Bone Mineral Density and Microstructure in Patients with Psoriatic Arthritis

BackgroundArterial calcification might be an important determinant of arterial stiffness. It has been suggested that vascular calcification might occur in parallel with demineralization of bone, with a reciprocal relationship between arterial stiffening and osteoporosis explaining the epidemiological association of osteoporosis with cardiovascular events. Patients with psoriatic arthritis (PsA) have increased risk of osteoporosis and arterial stiffness. Whether there is any association between volumetric BMD (vBMD)/microstructure and arterial stiffness has never been explored in PsA patients.ObjectivesThe aim of this study is to examine the association between vBMD/microstructural features and arterial stiffness in PsA patients.Methods85 PsA patients (43 males; age: 54±12 years) were included. Arterial stiffness was determined by branchial-ankle pulse wave velocity (PWV). vBMD and microstructural features of the distal radius were measured using high-resolution peripheral quantitative computed tomography (HR-pQCT).ResultsNo patients had overt cardiovascular diseases (CVD). Patients were divided into 2 groups based on whether their PWV value is < (Low PWV, N=40) or ≥1450 cm/s (High PWV, N=45). Patients in High PWV group were older (60±10 vs 49±10 years, p