SAT0403 Clinical Characteristics and Outcomes of Diffuse Alveolar Hemorrhage in Patients with Systemic Lupus Erythematosus

BackgroundDiffuse alveolar hemorrhage (DAH) is a life-threatening though rare manifestation of systemic lupus erythematosus (SLE). Early diagnosis is difficult since the occurrence is abrupt and both symptoms and radiographic findings of diffuse lung infiltration on thoracic CT are nonspecific. Since DAH has high early mortality, it is important to find the clinical features indicating DAH among SLE patients with diffuse lung infiltration and factors influencing its outcomes.ObjectivesTo identify the clinical features of DAH in SLE patients compared with other causes of acute diffuse lung infiltration in SLE patients, and to determine the influencing factors of early outcome of SLE-DAH.MethodsWe retrospectively collected the medical records of SLE patients, who had acute diffuse lung infiltration on thoracic CT in a single university hospital between January 2004 and August 2014. DAH was defined based on the clinical diagnosis, and we divided patients into two groups; DAH vs. non-DAH group. We compared the demographic and clinical characteristics and presenting symptoms between two groups. And then, we further analyzed the early mortality of SLE-DAH patients and factors affecting mortality in DAH patients.ResultsAmong the 815 SLE patients who checked thoracic CT, 47 patients with acute diffuse lung infiltration were selected for this study. Among them, 24 SLE patients (51.1%) were diagnosed as DAH, the rest of 23 patients (48.9%) formed non-DAH group; non-DAH group included various diseases such as CMV infection (n=2), pneumocystis infection (n=3), unspecified pneumonia (n=9), SLE associated lesions (n=7), and others (n=2). All of them were female and young: 29.6 years old in DAH group and 29.8 years old in non-DAH group. In the presenting symptoms, hemoptysis and dyspnea were more common in DAH group, while fever was more common in non-DAH group, though statistically not significant. In laboratory findings, hemoglobin level (8.2±0.3 vs. 10.0±0.4 g/dL, p