AB0890 Is There a Relationship Between Vitamin D and Schizophrenia?
BackgroundStudies suggest a neuroprotective role for vitamin D. Its deficit has been linked with various psychiatric disorders such as schizophrenia (1). Increase in the prevalence of schizophrenia has been associated with high latitudes, winter/spring births, migration, urbanicity and cold climates...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2015-06, Vol.74 (Suppl 2), p.1198-1198 |
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| creator | Grados, D. Salavert, J. Ramiro, N. Carriόn, M. Ramírez, N. Erra, A. |
| description | BackgroundStudies suggest a neuroprotective role for vitamin D. Its deficit has been linked with various psychiatric disorders such as schizophrenia (1). Increase in the prevalence of schizophrenia has been associated with high latitudes, winter/spring births, migration, urbanicity and cold climates (2,3). Vitamin D deficiency could be an important environmental risk factor, linking all of the previously exposed.ObjectivesWe aimed to determine whether patients with a first psychotic episode had low levels of vitamin D compared to controls, considering their final diagnoses (schizophrenia vs other psychoses).MethodsCross-sectional study in an acute inpatient psychiatric unit. Vitamin D (25-hydroxyvitamin D) was determined by direct competitive chemiluminescence immunoassay. Vitamin D levels (ng/ml) were considered optimum >30, insufficient 20–30 and deficient 0.05).Schizophrenic patients showed deficient average values (ng/ml) of vitamin D (mean 12.87, range 6-24.9). Vitamin D levels in the other psychoses patient group were higher but also deficient (mean 15.74, range 6-34.6). Controls presented higher levels of vitamin D, but still insufficient (mean 21.45, range 11.20-33.5).Vitamin D levels in the schizophrenia group were significantly lower compared to controls (CI 1.8 – 15.4; p |
| doi_str_mv | 10.1136/annrheumdis-2015-eular.3826 |
| format | Article |
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Its deficit has been linked with various psychiatric disorders such as schizophrenia (1). Increase in the prevalence of schizophrenia has been associated with high latitudes, winter/spring births, migration, urbanicity and cold climates (2,3). Vitamin D deficiency could be an important environmental risk factor, linking all of the previously exposed.ObjectivesWe aimed to determine whether patients with a first psychotic episode had low levels of vitamin D compared to controls, considering their final diagnoses (schizophrenia vs other psychoses).MethodsCross-sectional study in an acute inpatient psychiatric unit. Vitamin D (25-hydroxyvitamin D) was determined by direct competitive chemiluminescence immunoassay. Vitamin D levels (ng/ml) were considered optimum >30, insufficient 20–30 and deficient <20 (4). Final diagnosis was obtained from the outpatient mental health service after a 6 month follow-up.ResultsWe analyzed 27 patients with first-episode psychosis (13 with final diagnosis of schizophrenia and 14 of other psychoses) and 17 healthy controls, with no differences in mean age between the three groups (χ2 (2)=5.20, p>0.05).Schizophrenic patients showed deficient average values (ng/ml) of vitamin D (mean 12.87, range 6-24.9). Vitamin D levels in the other psychoses patient group were higher but also deficient (mean 15.74, range 6-34.6). Controls presented higher levels of vitamin D, but still insufficient (mean 21.45, range 11.20-33.5).Vitamin D levels in the schizophrenia group were significantly lower compared to controls (CI 1.8 – 15.4; p<0.009). No other significant differences were found between groups.ConclusionsWe observed deficient vitamin D levels in all the patients studied, being significantly lower for schizophrenic patients. Future studies are required to further examine this association in schizophrenia because vitamin D deficiency may be an easily modifiable risk factor by means of a cheap and save public health intervention.ReferencesBelvederi Murri, M., Respino, M., et al. 2013 Vitamin D and psychosis: mini meta-analysis. Schizophr Res 150, 235-239.McGrath, J. J., Eyles, D.W., et al. 2010 Neonatal vitamin D status and risk of schizophrenia: a populationbased case-control study. Arch Gen Psychiatry 67, 889-94.McGrath, J. J., Burne, T.H., et al. 2010 Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36, 1073-8.Holick, M.F. 2007 Vitamin D deficiency. N Engl J Med 357, 266-81.Disclosure of InterestNone declared</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2015-eular.3826</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><ispartof>Annals of the rheumatic diseases, 2015-06, Vol.74 (Suppl 2), p.1198-1198</ispartof><rights>2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2015 (c) 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b1852-9b5f634c287e1ca5cdc4b524dddc3941724933436a74fb8ae10871a2312e7f493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/74/Suppl_2/1198.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/74/Suppl_2/1198.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,315,781,785,3197,23576,27929,27930,77605,77636</link.rule.ids></links><search><creatorcontrib>Grados, D.</creatorcontrib><creatorcontrib>Salavert, J.</creatorcontrib><creatorcontrib>Ramiro, N.</creatorcontrib><creatorcontrib>Carriόn, M.</creatorcontrib><creatorcontrib>Ramírez, N.</creatorcontrib><creatorcontrib>Erra, A.</creatorcontrib><title>AB0890 Is There a Relationship Between Vitamin D and Schizophrenia?</title><title>Annals of the rheumatic diseases</title><description>BackgroundStudies suggest a neuroprotective role for vitamin D. Its deficit has been linked with various psychiatric disorders such as schizophrenia (1). Increase in the prevalence of schizophrenia has been associated with high latitudes, winter/spring births, migration, urbanicity and cold climates (2,3). Vitamin D deficiency could be an important environmental risk factor, linking all of the previously exposed.ObjectivesWe aimed to determine whether patients with a first psychotic episode had low levels of vitamin D compared to controls, considering their final diagnoses (schizophrenia vs other psychoses).MethodsCross-sectional study in an acute inpatient psychiatric unit. Vitamin D (25-hydroxyvitamin D) was determined by direct competitive chemiluminescence immunoassay. Vitamin D levels (ng/ml) were considered optimum >30, insufficient 20–30 and deficient <20 (4). Final diagnosis was obtained from the outpatient mental health service after a 6 month follow-up.ResultsWe analyzed 27 patients with first-episode psychosis (13 with final diagnosis of schizophrenia and 14 of other psychoses) and 17 healthy controls, with no differences in mean age between the three groups (χ2 (2)=5.20, p>0.05).Schizophrenic patients showed deficient average values (ng/ml) of vitamin D (mean 12.87, range 6-24.9). Vitamin D levels in the other psychoses patient group were higher but also deficient (mean 15.74, range 6-34.6). Controls presented higher levels of vitamin D, but still insufficient (mean 21.45, range 11.20-33.5).Vitamin D levels in the schizophrenia group were significantly lower compared to controls (CI 1.8 – 15.4; p<0.009). No other significant differences were found between groups.ConclusionsWe observed deficient vitamin D levels in all the patients studied, being significantly lower for schizophrenic patients. Future studies are required to further examine this association in schizophrenia because vitamin D deficiency may be an easily modifiable risk factor by means of a cheap and save public health intervention.ReferencesBelvederi Murri, M., Respino, M., et al. 2013 Vitamin D and psychosis: mini meta-analysis. Schizophr Res 150, 235-239.McGrath, J. J., Eyles, D.W., et al. 2010 Neonatal vitamin D status and risk of schizophrenia: a populationbased case-control study. Arch Gen Psychiatry 67, 889-94.McGrath, J. J., Burne, T.H., et al. 2010 Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36, 1073-8.Holick, M.F. 2007 Vitamin D deficiency. N Engl J Med 357, 266-81.Disclosure of InterestNone declared</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkE1Lw0AQhhdRsFb_w0LPqfuV_cCDtFq1UBC0el02yYZsaTZxN0H05MU_6i8xtR68ehpm5n1m4AFggtEUY8rPjfehsn1duJgQhNPE9lsTplQSfgBGmHE5jDk6BCOEEE2Y4uIYnMS4GVoksRyBxWyOpEJfH5_LCNeVDRYa-GC3pnONj5Vr4dx2r9Z6-Ow6UzsPr6HxBXzMK_fetFWw3pnLU3BUmm20Z791DJ5uFuuru2R1f7u8mq2SDMuUJCpLS05ZTqSwODdpXuQsSwkriiKnimFBmKKUUW4EKzNpLEZSYEMoJlaUw24MJvu7bWheehs7vWn64IeXGiuEhVCIkSF1sU_loYkx2FK3wdUmvGmM9M6b_uNN77zpH296522g-Z7O6s2_wG9-cXfi</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Grados, D.</creator><creator>Salavert, J.</creator><creator>Ramiro, N.</creator><creator>Carriόn, M.</creator><creator>Ramírez, N.</creator><creator>Erra, A.</creator><general>BMJ Publishing Group LTD</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201506</creationdate><title>AB0890 Is There a Relationship Between Vitamin D and Schizophrenia?</title><author>Grados, D. ; Salavert, J. ; Ramiro, N. ; Carriόn, M. ; Ramírez, N. ; Erra, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1852-9b5f634c287e1ca5cdc4b524dddc3941724933436a74fb8ae10871a2312e7f493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grados, D.</creatorcontrib><creatorcontrib>Salavert, J.</creatorcontrib><creatorcontrib>Ramiro, N.</creatorcontrib><creatorcontrib>Carriόn, M.</creatorcontrib><creatorcontrib>Ramírez, N.</creatorcontrib><creatorcontrib>Erra, A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grados, D.</au><au>Salavert, J.</au><au>Ramiro, N.</au><au>Carriόn, M.</au><au>Ramírez, N.</au><au>Erra, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AB0890 Is There a Relationship Between Vitamin D and Schizophrenia?</atitle><jtitle>Annals of the rheumatic diseases</jtitle><date>2015-06</date><risdate>2015</risdate><volume>74</volume><issue>Suppl 2</issue><spage>1198</spage><epage>1198</epage><pages>1198-1198</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>BackgroundStudies suggest a neuroprotective role for vitamin D. Its deficit has been linked with various psychiatric disorders such as schizophrenia (1). Increase in the prevalence of schizophrenia has been associated with high latitudes, winter/spring births, migration, urbanicity and cold climates (2,3). Vitamin D deficiency could be an important environmental risk factor, linking all of the previously exposed.ObjectivesWe aimed to determine whether patients with a first psychotic episode had low levels of vitamin D compared to controls, considering their final diagnoses (schizophrenia vs other psychoses).MethodsCross-sectional study in an acute inpatient psychiatric unit. Vitamin D (25-hydroxyvitamin D) was determined by direct competitive chemiluminescence immunoassay. Vitamin D levels (ng/ml) were considered optimum >30, insufficient 20–30 and deficient <20 (4). Final diagnosis was obtained from the outpatient mental health service after a 6 month follow-up.ResultsWe analyzed 27 patients with first-episode psychosis (13 with final diagnosis of schizophrenia and 14 of other psychoses) and 17 healthy controls, with no differences in mean age between the three groups (χ2 (2)=5.20, p>0.05).Schizophrenic patients showed deficient average values (ng/ml) of vitamin D (mean 12.87, range 6-24.9). Vitamin D levels in the other psychoses patient group were higher but also deficient (mean 15.74, range 6-34.6). Controls presented higher levels of vitamin D, but still insufficient (mean 21.45, range 11.20-33.5).Vitamin D levels in the schizophrenia group were significantly lower compared to controls (CI 1.8 – 15.4; p<0.009). No other significant differences were found between groups.ConclusionsWe observed deficient vitamin D levels in all the patients studied, being significantly lower for schizophrenic patients. Future studies are required to further examine this association in schizophrenia because vitamin D deficiency may be an easily modifiable risk factor by means of a cheap and save public health intervention.ReferencesBelvederi Murri, M., Respino, M., et al. 2013 Vitamin D and psychosis: mini meta-analysis. Schizophr Res 150, 235-239.McGrath, J. J., Eyles, D.W., et al. 2010 Neonatal vitamin D status and risk of schizophrenia: a populationbased case-control study. Arch Gen Psychiatry 67, 889-94.McGrath, J. J., Burne, T.H., et al. 2010 Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36, 1073-8.Holick, M.F. 2007 Vitamin D deficiency. N Engl J Med 357, 266-81.Disclosure of InterestNone declared</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/annrheumdis-2015-eular.3826</doi><tpages>1</tpages></addata></record> |
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| title | AB0890 Is There a Relationship Between Vitamin D and Schizophrenia? |
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