AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents
BackgroundThere is limited evidence comparing the types of patients initiated on different classes of biologic medications, and this information is critical when conducting comparative observational research among patients with RA.ObjectivesThis study compared baseline characteristics of biologic na...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2015-06, Vol.74 (Suppl 2), p.1052-1053 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Harrold, L.R. Gandhi, K.K. Etzel, C.J. Nadkarni, A. Saunders, K.C. Kelly, S. Kremer, J.M. |
| description | BackgroundThere is limited evidence comparing the types of patients initiated on different classes of biologic medications, and this information is critical when conducting comparative observational research among patients with RA.ObjectivesThis study compared baseline characteristics of biologic naïve rheumatoid arthritis (RA) patients initiating abatacept as compared to tumor necrosis factor inhibitors (TNFi), and other non-TNFi biologics and small molecules (non-TNFi/sm).MethodsBiologics naïve RA patients who initiated abatacept, TNFi and other non-TNFi/sm from 12/2005 to 8/2014 within the Corrona registry were identified. Initiation of first biologic or small molecule (first line use) was defined as first indication of biologic use for a patient that was previously naïve to any biologic or small molecule prior to initiation of study drug. Baseline characteristics at time of biologic initiation were captured including demographics, comorbid conditions, and RA disease characteristics including age at disease onset, disease duration, prior and concomitant medication use, and disease activity. Descriptive statistics were performed including t-tests and Chi-square tests comparing abatacept initiators to TNFi and other non-TNFi/sm initiators.ResultsAmong the 4,232 first time biologic users, 364 (9%) initiated abatacept, 3689 (87%) TNFi, and 179 (4%) other non-TNFi/sm. Abatacept initiators as compared to TNFi initiators were more likely to be older (62.8 years (yrs) vs 56 yrs; P |
| doi_str_mv | 10.1136/annrheumdis-2015-eular.2068 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1901778854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4322501807</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1274-fee71e8052925e7644cf0b4696dad85b1342d4c9c0a6cf2398b6b87f17f939b13</originalsourceid><addsrcrecordid>eNqVUUuO1DAQtRBINAN3sDRbMtiJ4ziwSreGYaSBQXzWVsWpdLuVxI3tILGbDefhEFyAM3ASHLoXwI5V6dX7VEmPkHPOLjgv5DOYJr_DeexsyHLGywznAfxFzqS6R1ZcSJXWkt0nK8ZYkYlaVg_JoxD2CTLF1Yr8aNYsyX7efd3sUhoOdtpS19O1dYPbWkObLU4xPKcbNx7AL-wawiJDmhweTERvQ7Qm_GV7A9-_fUb6bvkOorMdbXzceRttoG8h2iWUXk8JJ5BCmxYiGDzEpxTC6Rh2NDp6G3fo__2HwtTR9yMMA33tBjTzgCfmMXnQwxDwyWmekY8vLz9sXmU3t1fXm-Yma3leiaxHrDgqVuZ1XmIlhTA9a4WsZQedKlteiLwTpjYMpOnzolatbFXV86qvizrRZ-T8mHvw7tOMIeq9m_2UTmpeM15VSpUiqV4cVca7EDz2-uDtCP6L5kwvFeo_KtRLhfp3hXqpMLnl0d2O-_8y_gLOtqxv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1901778854</pqid></control><display><type>article</type><title>AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents</title><source>BMJ Journals - NESLi2</source><creator>Harrold, L.R. ; Gandhi, K.K. ; Etzel, C.J. ; Nadkarni, A. ; Saunders, K.C. ; Kelly, S. ; Kremer, J.M.</creator><creatorcontrib>Harrold, L.R. ; Gandhi, K.K. ; Etzel, C.J. ; Nadkarni, A. ; Saunders, K.C. ; Kelly, S. ; Kremer, J.M.</creatorcontrib><description>BackgroundThere is limited evidence comparing the types of patients initiated on different classes of biologic medications, and this information is critical when conducting comparative observational research among patients with RA.ObjectivesThis study compared baseline characteristics of biologic naïve rheumatoid arthritis (RA) patients initiating abatacept as compared to tumor necrosis factor inhibitors (TNFi), and other non-TNFi biologics and small molecules (non-TNFi/sm).MethodsBiologics naïve RA patients who initiated abatacept, TNFi and other non-TNFi/sm from 12/2005 to 8/2014 within the Corrona registry were identified. Initiation of first biologic or small molecule (first line use) was defined as first indication of biologic use for a patient that was previously naïve to any biologic or small molecule prior to initiation of study drug. Baseline characteristics at time of biologic initiation were captured including demographics, comorbid conditions, and RA disease characteristics including age at disease onset, disease duration, prior and concomitant medication use, and disease activity. Descriptive statistics were performed including t-tests and Chi-square tests comparing abatacept initiators to TNFi and other non-TNFi/sm initiators.ResultsAmong the 4,232 first time biologic users, 364 (9%) initiated abatacept, 3689 (87%) TNFi, and 179 (4%) other non-TNFi/sm. Abatacept initiators as compared to TNFi initiators were more likely to be older (62.8 years (yrs) vs 56 yrs; P<0.001), female (81% vs 75%; P=0.039), with a lower mean BMI (28.8 vs 29.9; P=0.007). In terms of RA characteristics, the abatacept initiators had older age at disease onset, greater disease duration, and were more likely to be unemployed or disabled (Table 1) as compared to the TNFi initiators. They also more frequently had prior and concomitant use of non-MTX nonbiologic disease modifying anti-rheumatic drugs (nbDMARDs), and lower doses of concomitant prednisone as compared to TNFi prednisone users. Similarly abatacept initiators as compared to non-TNFi/sm initiators were more likely to be older (62.8 yrs vs 60 yrs; P=0.025) at time of biologic/small molecule initiation. With regard to RA characteristics, abatacept initiators as compared to non-TNFi/sm initiators were more likely to have an older age of RA onset, more often on concomitant MTX and non-MTX nbDMARDs.ConclusionsIn a real world national cohort of biologic naïve RA patients, those initiated on abatacept had a different profile than those initiating TNFi and non-TNFi/sm. Specifically abatacept users were older at the time of biologic/small molecule initiation, had onset of RA at an older age, and were more frequently using concomitant non-MTX nbDMARDS. Additionally abatacept initiators had a longer disease duration as compared to TNFi initiators. These findings are consistent with data from real-world registries in the US and Europe.AcknowledgementsThis study is sponsored by Corrona, LLC. The Corrona RA registry has been supported through contracted subscriptions in the last two years by AbbVie, Amgen, Astra Zeneca, BMS, Genentech, Horizon Pharma USA, Janssen, Eli Lilly, Novartis, Pfizer, and UCB.Disclosure of InterestL. Harrold Grant/research support from: Corrona, LLC., K. Gandhi Employee of: Bristol-Myers Squibb, C. Etzel Employee of: Corrona, LLC., A. Nadkarni Employee of: Bristol-Myers Squibb, K. Saunders Employee of: Corrona, LLC., S. Kelly Employee of: Bristol-Myers Squibb, J. Kremer Shareholder of: Corrona, LLC., Consultant for: AbbVie, Amgen, BMS, Genentech, Lilly, Pfizer, Employee of: Corrona, LLC.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2015-eular.2068</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Limited</publisher><ispartof>Annals of the rheumatic diseases, 2015-06, Vol.74 (Suppl 2), p.1052-1053</ispartof><rights>2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2015 (c) 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/74/Suppl_2/1052.2.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/74/Suppl_2/1052.2.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3194,23569,27922,27923,77370,77401</link.rule.ids></links><search><creatorcontrib>Harrold, L.R.</creatorcontrib><creatorcontrib>Gandhi, K.K.</creatorcontrib><creatorcontrib>Etzel, C.J.</creatorcontrib><creatorcontrib>Nadkarni, A.</creatorcontrib><creatorcontrib>Saunders, K.C.</creatorcontrib><creatorcontrib>Kelly, S.</creatorcontrib><creatorcontrib>Kremer, J.M.</creatorcontrib><title>AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents</title><title>Annals of the rheumatic diseases</title><description>BackgroundThere is limited evidence comparing the types of patients initiated on different classes of biologic medications, and this information is critical when conducting comparative observational research among patients with RA.ObjectivesThis study compared baseline characteristics of biologic naïve rheumatoid arthritis (RA) patients initiating abatacept as compared to tumor necrosis factor inhibitors (TNFi), and other non-TNFi biologics and small molecules (non-TNFi/sm).MethodsBiologics naïve RA patients who initiated abatacept, TNFi and other non-TNFi/sm from 12/2005 to 8/2014 within the Corrona registry were identified. Initiation of first biologic or small molecule (first line use) was defined as first indication of biologic use for a patient that was previously naïve to any biologic or small molecule prior to initiation of study drug. Baseline characteristics at time of biologic initiation were captured including demographics, comorbid conditions, and RA disease characteristics including age at disease onset, disease duration, prior and concomitant medication use, and disease activity. Descriptive statistics were performed including t-tests and Chi-square tests comparing abatacept initiators to TNFi and other non-TNFi/sm initiators.ResultsAmong the 4,232 first time biologic users, 364 (9%) initiated abatacept, 3689 (87%) TNFi, and 179 (4%) other non-TNFi/sm. Abatacept initiators as compared to TNFi initiators were more likely to be older (62.8 years (yrs) vs 56 yrs; P<0.001), female (81% vs 75%; P=0.039), with a lower mean BMI (28.8 vs 29.9; P=0.007). In terms of RA characteristics, the abatacept initiators had older age at disease onset, greater disease duration, and were more likely to be unemployed or disabled (Table 1) as compared to the TNFi initiators. They also more frequently had prior and concomitant use of non-MTX nonbiologic disease modifying anti-rheumatic drugs (nbDMARDs), and lower doses of concomitant prednisone as compared to TNFi prednisone users. Similarly abatacept initiators as compared to non-TNFi/sm initiators were more likely to be older (62.8 yrs vs 60 yrs; P=0.025) at time of biologic/small molecule initiation. With regard to RA characteristics, abatacept initiators as compared to non-TNFi/sm initiators were more likely to have an older age of RA onset, more often on concomitant MTX and non-MTX nbDMARDs.ConclusionsIn a real world national cohort of biologic naïve RA patients, those initiated on abatacept had a different profile than those initiating TNFi and non-TNFi/sm. Specifically abatacept users were older at the time of biologic/small molecule initiation, had onset of RA at an older age, and were more frequently using concomitant non-MTX nbDMARDS. Additionally abatacept initiators had a longer disease duration as compared to TNFi initiators. These findings are consistent with data from real-world registries in the US and Europe.AcknowledgementsThis study is sponsored by Corrona, LLC. The Corrona RA registry has been supported through contracted subscriptions in the last two years by AbbVie, Amgen, Astra Zeneca, BMS, Genentech, Horizon Pharma USA, Janssen, Eli Lilly, Novartis, Pfizer, and UCB.Disclosure of InterestL. Harrold Grant/research support from: Corrona, LLC., K. Gandhi Employee of: Bristol-Myers Squibb, C. Etzel Employee of: Corrona, LLC., A. Nadkarni Employee of: Bristol-Myers Squibb, K. Saunders Employee of: Corrona, LLC., S. Kelly Employee of: Bristol-Myers Squibb, J. Kremer Shareholder of: Corrona, LLC., Consultant for: AbbVie, Amgen, BMS, Genentech, Lilly, Pfizer, Employee of: Corrona, LLC.</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVUUuO1DAQtRBINAN3sDRbMtiJ4ziwSreGYaSBQXzWVsWpdLuVxI3tILGbDefhEFyAM3ASHLoXwI5V6dX7VEmPkHPOLjgv5DOYJr_DeexsyHLGywznAfxFzqS6R1ZcSJXWkt0nK8ZYkYlaVg_JoxD2CTLF1Yr8aNYsyX7efd3sUhoOdtpS19O1dYPbWkObLU4xPKcbNx7AL-wawiJDmhweTERvQ7Qm_GV7A9-_fUb6bvkOorMdbXzceRttoG8h2iWUXk8JJ5BCmxYiGDzEpxTC6Rh2NDp6G3fo__2HwtTR9yMMA33tBjTzgCfmMXnQwxDwyWmekY8vLz9sXmU3t1fXm-Yma3leiaxHrDgqVuZ1XmIlhTA9a4WsZQedKlteiLwTpjYMpOnzolatbFXV86qvizrRZ-T8mHvw7tOMIeq9m_2UTmpeM15VSpUiqV4cVca7EDz2-uDtCP6L5kwvFeo_KtRLhfp3hXqpMLnl0d2O-_8y_gLOtqxv</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Harrold, L.R.</creator><creator>Gandhi, K.K.</creator><creator>Etzel, C.J.</creator><creator>Nadkarni, A.</creator><creator>Saunders, K.C.</creator><creator>Kelly, S.</creator><creator>Kremer, J.M.</creator><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201506</creationdate><title>AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents</title><author>Harrold, L.R. ; Gandhi, K.K. ; Etzel, C.J. ; Nadkarni, A. ; Saunders, K.C. ; Kelly, S. ; Kremer, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1274-fee71e8052925e7644cf0b4696dad85b1342d4c9c0a6cf2398b6b87f17f939b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrold, L.R.</creatorcontrib><creatorcontrib>Gandhi, K.K.</creatorcontrib><creatorcontrib>Etzel, C.J.</creatorcontrib><creatorcontrib>Nadkarni, A.</creatorcontrib><creatorcontrib>Saunders, K.C.</creatorcontrib><creatorcontrib>Kelly, S.</creatorcontrib><creatorcontrib>Kremer, J.M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrold, L.R.</au><au>Gandhi, K.K.</au><au>Etzel, C.J.</au><au>Nadkarni, A.</au><au>Saunders, K.C.</au><au>Kelly, S.</au><au>Kremer, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents</atitle><jtitle>Annals of the rheumatic diseases</jtitle><date>2015-06</date><risdate>2015</risdate><volume>74</volume><issue>Suppl 2</issue><spage>1052</spage><epage>1053</epage><pages>1052-1053</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>BackgroundThere is limited evidence comparing the types of patients initiated on different classes of biologic medications, and this information is critical when conducting comparative observational research among patients with RA.ObjectivesThis study compared baseline characteristics of biologic naïve rheumatoid arthritis (RA) patients initiating abatacept as compared to tumor necrosis factor inhibitors (TNFi), and other non-TNFi biologics and small molecules (non-TNFi/sm).MethodsBiologics naïve RA patients who initiated abatacept, TNFi and other non-TNFi/sm from 12/2005 to 8/2014 within the Corrona registry were identified. Initiation of first biologic or small molecule (first line use) was defined as first indication of biologic use for a patient that was previously naïve to any biologic or small molecule prior to initiation of study drug. Baseline characteristics at time of biologic initiation were captured including demographics, comorbid conditions, and RA disease characteristics including age at disease onset, disease duration, prior and concomitant medication use, and disease activity. Descriptive statistics were performed including t-tests and Chi-square tests comparing abatacept initiators to TNFi and other non-TNFi/sm initiators.ResultsAmong the 4,232 first time biologic users, 364 (9%) initiated abatacept, 3689 (87%) TNFi, and 179 (4%) other non-TNFi/sm. Abatacept initiators as compared to TNFi initiators were more likely to be older (62.8 years (yrs) vs 56 yrs; P<0.001), female (81% vs 75%; P=0.039), with a lower mean BMI (28.8 vs 29.9; P=0.007). In terms of RA characteristics, the abatacept initiators had older age at disease onset, greater disease duration, and were more likely to be unemployed or disabled (Table 1) as compared to the TNFi initiators. They also more frequently had prior and concomitant use of non-MTX nonbiologic disease modifying anti-rheumatic drugs (nbDMARDs), and lower doses of concomitant prednisone as compared to TNFi prednisone users. Similarly abatacept initiators as compared to non-TNFi/sm initiators were more likely to be older (62.8 yrs vs 60 yrs; P=0.025) at time of biologic/small molecule initiation. With regard to RA characteristics, abatacept initiators as compared to non-TNFi/sm initiators were more likely to have an older age of RA onset, more often on concomitant MTX and non-MTX nbDMARDs.ConclusionsIn a real world national cohort of biologic naïve RA patients, those initiated on abatacept had a different profile than those initiating TNFi and non-TNFi/sm. Specifically abatacept users were older at the time of biologic/small molecule initiation, had onset of RA at an older age, and were more frequently using concomitant non-MTX nbDMARDS. Additionally abatacept initiators had a longer disease duration as compared to TNFi initiators. These findings are consistent with data from real-world registries in the US and Europe.AcknowledgementsThis study is sponsored by Corrona, LLC. The Corrona RA registry has been supported through contracted subscriptions in the last two years by AbbVie, Amgen, Astra Zeneca, BMS, Genentech, Horizon Pharma USA, Janssen, Eli Lilly, Novartis, Pfizer, and UCB.Disclosure of InterestL. Harrold Grant/research support from: Corrona, LLC., K. Gandhi Employee of: Bristol-Myers Squibb, C. Etzel Employee of: Corrona, LLC., A. Nadkarni Employee of: Bristol-Myers Squibb, K. Saunders Employee of: Corrona, LLC., S. Kelly Employee of: Bristol-Myers Squibb, J. Kremer Shareholder of: Corrona, LLC., Consultant for: AbbVie, Amgen, BMS, Genentech, Lilly, Pfizer, Employee of: Corrona, LLC.</abstract><cop>Kidlington</cop><pub>Elsevier Limited</pub><doi>10.1136/annrheumdis-2015-eular.2068</doi><tpages>2</tpages></addata></record> |
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| title | AB0468 Channeling of Biologic Agents: Comparing Baseline Characteristics of Biologic Naïve Rheumatoid Arthritis Patients Initiating Abatacept, as Compared to Other Biologic Agents and Small Molecule Agents |
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