TGF-[beta]1 promotes acinar to ductal metaplasia of human pancreatic acinar cells

Animal studies suggest that pancreatitis-induced acinar-to-ductal metaplasia (ADM) is a key event for pancreatic ductal adenocarcinoma (PDAC) initiation. However, there has not been an adequate system to explore the mechanisms of human ADM induction. We have developed a flow cytometry-based, high re...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6, p.30904
Hauptverfasser:	Liu, Jun, Akanuma, Naoki, Liu, Chengyang, Naji, Ali, Halff, Glenn A, Washburn, William K, Sun, Luzhe, Wang, Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Adenocarcinoma Cell culture Cell proliferation Flow cytometry K-Ras protein Metaplasia Pancreas Pancreatic cancer Pancreatic diseases Pancreatitis Rodents Smad protein Transforming growth factor-b1
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