BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis

Human polyomaviruses are ubiquitous, with primary infections that typically occur during childhood and subsequent latency that may last a lifetime. Polyomavirus‐mediated disease has been described in immunocompromised patients; its relationship to oncogenesis is poorly understood. We present deep se...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of transplantation 2017-06, Vol.17 (6), p.1674-1680
Hauptverfasser:	Kenan, D. J., Mieczkowski, P. A., Latulippe, E., Côté, I., Singh, H. K., Nickeleit, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen T (large) Antigens Antigens, Viral, Tumor - genetics Antigens, Viral, Tumor - metabolism basic (laboratory) research/science BK Virus - genetics cancer/malignancy/neoplasia Carcinogenesis - genetics Case reports Children Chromosome 2 clinical research/practice Feedback Genome, Human Genomes Genomics Genotype High-Throughput Nucleotide Sequencing Humans Immunocompromised hosts Immunohistochemistry infection and infectious agents infectious disease Integration kidney (allograft) function/dysfunction Kidney cancer Kidney Neoplasms - etiology Kidney Neoplasms - metabolism Kidney transplantation kidney transplantation/nephrology Latency Male Malignancy Middle Aged molecular biology: DNA Nephropathy pathology/histopathology Polyomavirus Infections - complications Polyomavirus Infections - genetics Polyomavirus Infections - virology Prognosis Renal cell carcinoma Transplantation Tumor cells Tumor Virus Infections - complications Tumor Virus Infections - genetics Tumor Virus Infections - virology Tumorigenesis viral: BK/JC/polyoma Virus Integration - genetics Virus Replication VP1 protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!