Preparation of metal ion-mediated Furosemide molecularly imprinted polymer: synthesis, characterization, and drug release studies
In the present study, a molecularly imprinted polymer (MIP) was prepared for Furosemide drug as template molecule in H 2 O/THF (1:1 v / v ) medium using Fe 3+ as metal ion mediator. Acrylic acid, acrylamide, and N , N′ -methylenebis(acrylamide) were used as functional monomer, comonomer, and cross-l...
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| Veröffentlicht in: | Colloid and polymer science 2017-06, Vol.295 (6), p.945-957 |
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| creator | Fareghi, Amir Reza Moghadam, Peyman Najafi Khalafy, Jabbar |
| description | In the present study, a molecularly imprinted polymer (MIP) was prepared for Furosemide drug as template molecule in H
2
O/THF (1:1
v
/
v
) medium using Fe
3+
as metal ion mediator. Acrylic acid, acrylamide, and
N
,
N′
-methylenebis(acrylamide) were used as functional monomer, comonomer, and cross-linking agent, respectively. Different binding and selectivity parameters of the prepared system were studied and compared with the corresponding metal ion-free MIP and non-imprinted polymer (NIP). The presence of the metal ion during pre-assembly step showed a significant influence on the imprinting ability of the resulting polymeric network due to its strong interactions with the template molecule and the functional monomer. Besides, structural, thermal, and morphological characterizations of the prepared system were investigated. In the final step, the in vitro release study of Furosemide from the synthesized polymers was carried out in pH = 7.41 phosphate-buffered saline solution at 37 °C. Results indicated that the Fe
3+
-mediated MIP (Fe-MIP) has larger drug loading capacity and higher amount of drug release at its equilibrium state. Moreover, according to the drug release profiles, the drug release rate of the Fe-MIP is more controlled than that of the MIP and the NIP, especially at the early stages of release. |
| doi_str_mv | 10.1007/s00396-017-4081-1 |
| format | Article |
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2
O/THF (1:1
v
/
v
) medium using Fe
3+
as metal ion mediator. Acrylic acid, acrylamide, and
N
,
N′
-methylenebis(acrylamide) were used as functional monomer, comonomer, and cross-linking agent, respectively. Different binding and selectivity parameters of the prepared system were studied and compared with the corresponding metal ion-free MIP and non-imprinted polymer (NIP). The presence of the metal ion during pre-assembly step showed a significant influence on the imprinting ability of the resulting polymeric network due to its strong interactions with the template molecule and the functional monomer. Besides, structural, thermal, and morphological characterizations of the prepared system were investigated. In the final step, the in vitro release study of Furosemide from the synthesized polymers was carried out in pH = 7.41 phosphate-buffered saline solution at 37 °C. Results indicated that the Fe
3+
-mediated MIP (Fe-MIP) has larger drug loading capacity and higher amount of drug release at its equilibrium state. Moreover, according to the drug release profiles, the drug release rate of the Fe-MIP is more controlled than that of the MIP and the NIP, especially at the early stages of release.</description><identifier>ISSN: 0303-402X</identifier><identifier>EISSN: 1435-1536</identifier><identifier>DOI: 10.1007/s00396-017-4081-1</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acrylamide ; Acrylic acid ; Characterization and Evaluation of Materials ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Crosslinking ; Ferric ions ; Food Science ; Imprinted polymers ; Monomers ; Nanotechnology and Microengineering ; Original Contribution ; Physical Chemistry ; Polymer Sciences ; Polymers ; Saline solutions ; Soft and Granular Matter</subject><ispartof>Colloid and polymer science, 2017-06, Vol.295 (6), p.945-957</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Colloid and Polymer Science is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-9974ba91b22d4c800150bc9f75a05e93842d409a5b4b30fc77e5ff2aa441e13d3</citedby><cites>FETCH-LOGICAL-c316t-9974ba91b22d4c800150bc9f75a05e93842d409a5b4b30fc77e5ff2aa441e13d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00396-017-4081-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00396-017-4081-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Fareghi, Amir Reza</creatorcontrib><creatorcontrib>Moghadam, Peyman Najafi</creatorcontrib><creatorcontrib>Khalafy, Jabbar</creatorcontrib><title>Preparation of metal ion-mediated Furosemide molecularly imprinted polymer: synthesis, characterization, and drug release studies</title><title>Colloid and polymer science</title><addtitle>Colloid Polym Sci</addtitle><description>In the present study, a molecularly imprinted polymer (MIP) was prepared for Furosemide drug as template molecule in H
2
O/THF (1:1
v
/
v
) medium using Fe
3+
as metal ion mediator. Acrylic acid, acrylamide, and
N
,
N′
-methylenebis(acrylamide) were used as functional monomer, comonomer, and cross-linking agent, respectively. Different binding and selectivity parameters of the prepared system were studied and compared with the corresponding metal ion-free MIP and non-imprinted polymer (NIP). The presence of the metal ion during pre-assembly step showed a significant influence on the imprinting ability of the resulting polymeric network due to its strong interactions with the template molecule and the functional monomer. Besides, structural, thermal, and morphological characterizations of the prepared system were investigated. In the final step, the in vitro release study of Furosemide from the synthesized polymers was carried out in pH = 7.41 phosphate-buffered saline solution at 37 °C. Results indicated that the Fe
3+
-mediated MIP (Fe-MIP) has larger drug loading capacity and higher amount of drug release at its equilibrium state. Moreover, according to the drug release profiles, the drug release rate of the Fe-MIP is more controlled than that of the MIP and the NIP, especially at the early stages of release.</description><subject>Acrylamide</subject><subject>Acrylic acid</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Crosslinking</subject><subject>Ferric ions</subject><subject>Food Science</subject><subject>Imprinted polymers</subject><subject>Monomers</subject><subject>Nanotechnology and Microengineering</subject><subject>Original Contribution</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Saline solutions</subject><subject>Soft and Granular Matter</subject><issn>0303-402X</issn><issn>1435-1536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kD1PwzAQhi0EEqXwA9gssdZwjp0Ps6GKAlIlGEBis5zk0qbKF3YyhI1_jkMYWJhOd_e-7-keQi45XHOA-MYBCBUx4DGTkHDGj8iCSxEyHoromCxAgPCb4P2UnDl3AACpomhBvl4sdsaavmwb2ha0xt5U1Desxrw0PeZ0M9jWYV3mSOu2wmyojK1GWtadLZtJ0LXVWKO9pW5s-j260q1otvehWY-2_PzJXlHT5DS3w45arNA4pK4f8hLdOTkpTOXw4rcuydvm_nX9yLbPD0_ruy3LBI96plQsU6N4GgS5zBIAHkKaqSIODYSoRCL9HJQJU5kKKLI4xrAoAmOk5MhFLpbkas7tbPsxoOv1oR1s409qnigVqTAWkVfxWZX5p53FQvsva2NHzUFPpPVMWnvSeiKtufcEs8dNRHZo_yT_a_oGuVKDpA</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Fareghi, Amir Reza</creator><creator>Moghadam, Peyman Najafi</creator><creator>Khalafy, Jabbar</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170601</creationdate><title>Preparation of metal ion-mediated Furosemide molecularly imprinted polymer: synthesis, characterization, and drug release studies</title><author>Fareghi, Amir Reza ; Moghadam, Peyman Najafi ; Khalafy, Jabbar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-9974ba91b22d4c800150bc9f75a05e93842d409a5b4b30fc77e5ff2aa441e13d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acrylamide</topic><topic>Acrylic acid</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Crosslinking</topic><topic>Ferric ions</topic><topic>Food Science</topic><topic>Imprinted polymers</topic><topic>Monomers</topic><topic>Nanotechnology and Microengineering</topic><topic>Original Contribution</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Saline solutions</topic><topic>Soft and Granular Matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fareghi, Amir Reza</creatorcontrib><creatorcontrib>Moghadam, Peyman Najafi</creatorcontrib><creatorcontrib>Khalafy, Jabbar</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>https://resources.nclive.org/materials</collection><collection>Materials science collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Colloid and polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fareghi, Amir Reza</au><au>Moghadam, Peyman Najafi</au><au>Khalafy, Jabbar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of metal ion-mediated Furosemide molecularly imprinted polymer: synthesis, characterization, and drug release studies</atitle><jtitle>Colloid and polymer science</jtitle><stitle>Colloid Polym Sci</stitle><date>2017-06-01</date><risdate>2017</risdate><volume>295</volume><issue>6</issue><spage>945</spage><epage>957</epage><pages>945-957</pages><issn>0303-402X</issn><eissn>1435-1536</eissn><abstract>In the present study, a molecularly imprinted polymer (MIP) was prepared for Furosemide drug as template molecule in H
2
O/THF (1:1
v
/
v
) medium using Fe
3+
as metal ion mediator. Acrylic acid, acrylamide, and
N
,
N′
-methylenebis(acrylamide) were used as functional monomer, comonomer, and cross-linking agent, respectively. Different binding and selectivity parameters of the prepared system were studied and compared with the corresponding metal ion-free MIP and non-imprinted polymer (NIP). The presence of the metal ion during pre-assembly step showed a significant influence on the imprinting ability of the resulting polymeric network due to its strong interactions with the template molecule and the functional monomer. Besides, structural, thermal, and morphological characterizations of the prepared system were investigated. In the final step, the in vitro release study of Furosemide from the synthesized polymers was carried out in pH = 7.41 phosphate-buffered saline solution at 37 °C. Results indicated that the Fe
3+
-mediated MIP (Fe-MIP) has larger drug loading capacity and higher amount of drug release at its equilibrium state. Moreover, according to the drug release profiles, the drug release rate of the Fe-MIP is more controlled than that of the MIP and the NIP, especially at the early stages of release.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00396-017-4081-1</doi><tpages>13</tpages></addata></record> |
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| subjects | Acrylamide Acrylic acid Characterization and Evaluation of Materials Chemical synthesis Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Crosslinking Ferric ions Food Science Imprinted polymers Monomers Nanotechnology and Microengineering Original Contribution Physical Chemistry Polymer Sciences Polymers Saline solutions Soft and Granular Matter |
| title | Preparation of metal ion-mediated Furosemide molecularly imprinted polymer: synthesis, characterization, and drug release studies |
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