Insulin-degrading enzyme prevents [alpha]-synuclein fibril formation in a nonproteolytical manner

The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β (Αβ) and Islet Amyloid Polypeptide (IAPP), i.e. peptides associated with Alzheimer's disease and type 2 diabetes, respectively. In addition to the protease activity normally associated with IDE function an addi...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5, p.12531
Hauptverfasser:	Sharma, Sandeep K, Chorell, Erik, Steneberg, Pär, Vernersson-lindahl, Emma, Edlund, Helena, Wittung-stafshede, Pernilla
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amylin Amyloid Amyloidogenesis Diabetes mellitus Enzymes Insulin Insulysin Movement disorders Neurodegenerative diseases Parkinson's disease Peptides Proteases Proteinase Proteolysis Synuclein
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