rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NF[kappa]B upon 5-FU treatment

5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application. In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein st...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6, p.38369
Hauptverfasser:	Russo, Annapina, Saide, Assunta, Cagliani, Roberta, Cantile, Monica, Botti, Gerardo, Russo, Giulia
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis BAX protein Bcl protein Bcl-2 protein Cell adhesion & migration Cell migration Chemotherapy Drug resistance Lung cancer NF-κB protein Nuclear transport p53 Protein Proteins Transcription Translocation
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