High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A [beta]-lactamase, PenL

The omega loop in β-lactamases plays a pivotal role in substrate recognition and catalysis, and some mutations in this loop affect the adaptability of the enzymes to new antibiotics. Various mutations, including substitutions, deletions, and intragenic duplications resulting in tandem repeats (TRs),...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6, p.36527
Hauptverfasser:	Yi, Hyojeong, Choi, Jin Myung, Hwang, Junghyun, Prati, Fabio, Cao, Thinh-phat, Lee, Sung Haeng, Kim, Heenam Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptability Adaptation Amino acids Antibiotics Catalysis Enzymes Evolution Mutation Substrates
Online-Zugang:	Volltext
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