Pharmacokinetic comparison and bioequivalence evaluation of two 10-mg baclofen formulations in healthy male subjects

Baclofen is used as a skeletal muscle relaxant for multiple sclerosis patients. It depresses the transmission of monosynaptic and polysynaptic reflex by stimulating GABA (gamma-aminobutyric acid) receptors. The aim of this study was to compare the pharmacokinetic characteristics of two 10-mg baclofe...

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Veröffentlicht in:	International journal of clinical pharmacology and therapeutics 2017-02, Vol.55 (2), p.194-200
Hauptverfasser:	Yoon, Sumin, Lee, SeungHwan, Yu, Kyung-Sang, Yim, Sung-Vin, Kim, Bo-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Baclofen - administration & dosage Baclofen - adverse effects Baclofen - pharmacokinetics Bioequivalence Cross-Over Studies Drug Compounding Drug dosages Half-Life Healthy Volunteers Humans Male Metabolic Clearance Rate Middle Aged Models, Biological Muscle Relaxants, Central - administration & dosage Muscle Relaxants, Central - adverse effects Muscle Relaxants, Central - pharmacokinetics Pharmacokinetics Pharmacology Plasma Republic of Korea Spasticity Spinal cord injuries Therapeutic Equivalency University colleges
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