TGF-[beta] induces p53/Smads complex formation in the PAI-1 promoter to activate transcription

Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for tumor suppression during the early stages. However, the mechanism of functional switching of TGF-β is still unknown, and it is unclear whether i...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6, p.35483
Hauptverfasser:	Kawarada, Yuki, Inoue, Yasumichi, Kawasaki, Fumihiro, Fukuura, Keishi, Sato, Koichi, Tanaka, Takahito, Itoh, Yuka, Hayashi, Hidetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes Inactivation p53 Protein Signal transduction Transducers Transforming growth factor-b Tumor suppression Tumorigenesis
Online-Zugang:	Volltext
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