B cell-derived transforming growth factor-[beta]1 expression limits the induction phase of autoimmune neuroinflammation

Studies in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), have shown that regulatory B cells modulate the course of the disease via the production of suppressive cytokines. While data indicate a role for transforming growth factor (TGF)-β1 expression in r...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6, p.34594
Hauptverfasser:	Bjarnadóttir, Kristbjörg, Benkhoucha, Mahdia, Merkler, Doron, Weber, Martin S, Payne, Natalie L, Bernard, Claude C A, Molnarfi, Nicolas, Lalive, Patrice H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antigen-presenting cells Cell activation Central nervous system Cytokines Dendritic cells Experimental allergic encephalomyelitis Growth factors Inflammation Lymphocytes B Lymphocytes T Multiple sclerosis Myelin Oligodendrocyte-myelin glycoprotein Rodents T cell receptors Transforming growth factor-b1 Transgenic mice
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