Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-[beta]/Smad pathway of fibrosis in human keratocytes in vitro

Corneal wound healing is often affected by TGF-β-mediated fibrosis and scar formation. Guided fibrosis with IGF-1 and antifibrotic substances might maintain corneal transparency. Primary human corneal keratocytes under serum-free conditions were used as a model of corneal stromal wounding, with mark...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6, p.34373
Hauptverfasser:	Sarenac, Tomislav, Trapecar, Martin, Gradisnik, Lidija, Rupnik, Marjan Slak, Pahor, Dusica
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase Aldehydes Cornea Crystallin Dehydrogenase Dehydrogenases Extracellular matrix Fibroblasts Fibrosis Flow cytometry Immunofluorescence Insulin-like growth factor I Opacity Proteoglycans Smad protein Smad3 protein Smad7 protein Translocation Wound healing
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