The Wnt/[beta]-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells

Hypoxia, a feature common to most solid tumors, is known to regulate many aspects of tumorigenesis. Recently, it was suggested that hypoxia increased the size of the cancer stem-cell (CSC) subpopulations and promoted the acquisition of a CSC-like phenotype. However, candidate hypoxia-regulated media...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6, p.22966
Hauptverfasser:	Dong, Hye-jin, Jang, Gyu-beom, Lee, Hwa-yong, Park, Se-ra, Kim, Ji-young, Nam, Jeong-seok, Hong, In-sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer CD44 antigen Cell self-renewal Colorectal cancer Hypoxia Metastases Solid tumors Stem cells Subpopulations Tumorigenesis Wnt protein β-Catenin
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