Neuroinflammation and A[beta] Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

Alzheimer's disease (AD) is a neurodegenerative disorder, marked by senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have suggested that systemic inflammation could contribute to neuroinflammation and enhanced Aβ cer...

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Veröffentlicht in:	Scientific reports 2015-02, Vol.5, p.8489
Hauptverfasser:	Carret-rebillat, Anne-sophie, Pace, Clarisse, Gourmaud, Sarah, Ravasi, Laura, Montagne-stora, Samantha, Longueville, Sophie, Tible, Marion, Sudol, Erika, Chang, Raymond Chuen-chung, Paquet, Claire, Mouton-liger, François, Hugon, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Apoptosis Cerebrospinal fluid Hippocampus Inflammation Lipopolysaccharides Neurodegenerative diseases Neurofibrillary tangles Neuroimaging Positron emission tomography Rodents Senile plaques Stat3 protein Transcription β-Amyloid β-Site APP-cleaving enzyme 1
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