[alpha]2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction

Renal fibrosis is the final common pathway of a wide variety of chronic kidney diseases. Myofibroblast formation via the differentiation of from tissue-resident fibroblasts and bone marrow-derived mesenchymal stem cells (MSCs), and epithelial-to-mesenchymal transition (EMT) is known to play a pivota...

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Veröffentlicht in:	Scientific reports 2014-08, Vol.4, p.5967
Hauptverfasser:	Kanno, Yosuke, Kawashita, Eri, Kokado, Akiko, Kuretake, Hiromi, Ikeda, Kanako, Okada, Kiyotaka, Seishima, Mariko, Ueshima, Shigeru, Matsuo, Osamu, Matsuno, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow c-Jun protein Enzyme inhibitors Epithelial cells Fibroblasts Fibrosis JNK protein Kidneys Mesenchyme Rodents Stem cell transplantation Stem cells Transcription factors
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