Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta‐Analysis

Azathioprine, a purine antimetabolite immunosuppressant, photosensitizes the skin and causes the production of mutagenic reactive oxygen species. It is postulated to increase the risk of squamous cell carcinoma (SCC) and other skin cancers in organ transplant recipients (OTRs), but evidence from mul...

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Veröffentlicht in:	American journal of transplantation 2016-12, Vol.16 (12), p.3490-3503
Hauptverfasser:	Jiyad, Z., Olsen, C. M., Burke, M. T., Isbel, N. M., Green, A. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	antiproliferative agent: azathioprine (AZA) Azathioprine Azathioprine - adverse effects Basal cell carcinoma cancer/malignancy/neoplasia: risk factors cancer/malignancy/neoplasia: skin Carcinogenicity Carcinoma, Basal Cell - chemically induced Carcinoma, Basal Cell - epidemiology Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - epidemiology clinical research/practice dermatology Estimates Evidence-based medicine Graft Rejection - drug therapy Graft Rejection - etiology Health risk assessment Humans immunosuppressant Immunosuppressive agents Immunosuppressive Agents - adverse effects Meta-analysis nonmelanoma Organ Transplantation - adverse effects Postoperative Complications Prognosis Reactive oxygen species Risk Factors Skin cancer Skin Neoplasms - chemically induced Skin Neoplasms - epidemiology Squamous cell carcinoma Systematic review
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