Comparing Effects of Intraventricular Hypertonic Saline and Magnesium Sulfate Application on Diffuse Brain Injury in Rats/Ratlardaki Diffüz Beyin Travmasinda Hipertonik Salin ve Magnezyum Sülfatin Intraventriküler Uygulamayla Etkilerinin Karsilastirilmasi
The aim of the study was to compare the effects of magnesium sulfate and hypertonic saline on diffuse brain injury in rats. [...]the number of damaged neurons did not show significant difference between hypertonic saline and control groups, it was significantly lower in magnesium group (p
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| Veröffentlicht in: | Türk yogun bakim dergisi 2017-04, Vol.15 (1), p.34 |
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| container_title | Türk yogun bakim dergisi |
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| creator | Kizilcik, Nurcan Çelikoglu, Erhan Kelestemur, Taha Köner, Özge Is, Merih Bilgen, Sevgi Çeçen, Ayçiçek Yilmaz, Bayram |
| description | The aim of the study was to compare the effects of magnesium sulfate and hypertonic saline on diffuse brain injury in rats. [...]the number of damaged neurons did not show significant difference between hypertonic saline and control groups, it was significantly lower in magnesium group (p |
| doi_str_mv | 10.4274/tybdd.08870 |
| format | Article |
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[...]the number of damaged neurons did not show significant difference between hypertonic saline and control groups, it was significantly lower in magnesium group (p<0.05). [...]by producing hemodilution and red cell deformity, mannitol increases blood flow to the tissues and reduces cerebrospinal fluid release from the choroids plexus (6,7). Magnesium sulfate is a noncompetitive inhibitor of the N-methyl-D aspartic acid (NMDA) receptors and ion channels in the brain, providing protective effect on blood brain barrier in experimental models (12). Studies on the effect of magnesium or hypertonic saline in experimental models commonly applied intraperitoneal or intra-arterial way of drug administration (13,14). In the present study, we compared the direct intraventricular effects of hypertonic saline a well-known osmotic agent decreasing intracranial pressure and magnesium sulphate an NMDA receptor inhibitor that has recently-shown to have neuroprotective effects on injured neuron cells after brain trauma in rats. Materials and Methods Study Design and Animals This was an experimental study in which 18 male Sprague-Dawley rats weighing 250-300 gr were used. 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| source | Alma/SFX Local Collection |
| subjects | Anesthesiology Blood-brain barrier Drug dosages Edema Head injuries Intensive care Laboratory animals Medical research Neurons Osmosis Rodents Studies Trauma Traumatic brain injury |
| title | Comparing Effects of Intraventricular Hypertonic Saline and Magnesium Sulfate Application on Diffuse Brain Injury in Rats/Ratlardaki Diffüz Beyin Travmasinda Hipertonik Salin ve Magnezyum Sülfatin Intraventriküler Uygulamayla Etkilerinin Karsilastirilmasi |
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