Dual action of high estradiol doses on MNU‐induced prostate neoplasms in a rodent model with high serum testosterone: Protective effect and emergence of unstable epithelial microenvironment

BACKGROUND Estrogens are critical players in prostate growth and disease. Estrogen therapy has been the standard treatment for advanced prostate cancer for several decades; however, it has currently been replaced by alternative anti‐androgenic therapies. Additionally, studies of its action on prosta...

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Veröffentlicht in:	The Prostate 2017-06, Vol.77 (9), p.970-983
Hauptverfasser:	Gonçalves, Bianca F., de Campos, Silvana G.P., Góes, Rejane M., Scarano, Wellerson R., Taboga, Sebastião R., Vilamaior, Patricia S.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Androgens Androgens - metabolism Androgens - pharmacology Animals Basal cells cancer Carcinogenesis Carcinogenesis - drug effects Carcinogenesis - pathology Carcinogens Carcinogens - pharmacology Disease Progression DNA Damage - drug effects DNA damage/repair DNA methylation Epithelial Cells - pathology Epithelium Estradiol - metabolism Estradiol - pharmacology Estrogen receptors Estrogens exocrine glands light microscopy Male Methylnitrosourea - pharmacology Neoplasia Prostate Prostate - drug effects Prostate - pathology Prostate cancer Prostatic Neoplasms - chemically induced Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology Prostatic Neoplasms - prevention & control Protective Factors Rats reproductive biology Testosterone Tumors
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