Microglia-derived IL-1Beta promotes chemokine expression by Muller cells and RPE in focal retinal degeneration

Background Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related macular degeneration (AMD). Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines Ccl2, Cxcl...

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Veröffentlicht in:	Molecular neurodegeneration 2017-01, Vol.12
Hauptverfasser:	Natoli, Riccardo, Nilisha Fernando, Madigan, Michele, Chu-Tan, Joshua A, Valter, Krisztina, Provis, Jan, Rutar, Matt
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Cell death Chemokines CXCL10 protein Immunohistochemistry Inflammasomes Inflammation Interleukin 1 Kinases Leukocyte migration Leukocytes Ligands Macrophages Macular degeneration Microglia Monocyte chemoattractant protein 1 Photoreceptors Proteins Recruitment Retina Retinal degeneration siRNA Studies
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