Comparing thrombin generation in patients with hemophilia A and patients on vitamin K antagonists

Essentials It is unknown if hemophilia patients with atrial fibrillation need anticoagulation. Endogenous thrombin potentials (ETP) in hemophilia patients and patients on coumarins were compared. Severe hemophilia patients had comparable ETP to therapeutic international normalized ratio (INR). In no...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2017-05, Vol.15 (5), p.868-875
Hauptverfasser:	Koning, M. L. Y., Fischer, K., Laat, B., Huisman, A., Ninivaggi, M., Schutgens, R. E. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acenocoumarol - administration & dosage Acenocoumarol - adverse effects Adolescent Adult Aged Antagonists Anticoagulants - administration & dosage Anticoagulants - adverse effects atrial fibrillation Atrial Fibrillation - blood Atrial Fibrillation - diagnosis Atrial Fibrillation - drug therapy Blood Coagulation - drug effects Cardiac arrhythmia Case-Control Studies Coagulation coumarins Cross-Sectional Studies Drug Monitoring - methods factor VIII Female Fibrillation Hemophilia hemophilia A Hemophilia A - blood Hemophilia A - diagnosis Hemostasis - drug effects Humans International Normalized Ratio Kinetics Male Middle Aged Phenprocoumon - administration & dosage Phenprocoumon - adverse effects Severity of Illness Index Thrombin Thrombin - metabolism Tissue factor Vitamin K Vitamin K - antagonists & inhibitors Young Adult
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