Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice

Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B‐cell function and development, we created transgenic (Tg) mice expressing a phosphorylation‐defective mutant of succi...

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Veröffentlicht in:	European journal of immunology 2017-02, Vol.47 (2), p.406-418
Hauptverfasser:	Ogura, Masato, Inoue, Takeshi, Yamaki, Junko, Homma, Miwako K., Kurosaki, Tomohiro, Homma, Yoshimi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis Animals Antigens Antigens, CD19 - genetics Antigens, CD19 - metabolism B cells B-Lymphocytes - immunology Calcium (intracellular) CD19 antigen Cell proliferation Cells, Cultured Defective mutant Electron Transport Complex II - genetics Electron Transport Complex II - metabolism Female Gender difference Immune response (humoral) Immune responses Immunity, Humoral Immunization Immunoglobulin G Immunoglobulin M Immunosuppression Lymphocytes B Lymphocytes T Male Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria Mitochondria - metabolism Mutation - genetics Oxidative stress Phosphorylation Phosphorylation - genetics Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Antigen, B-Cell - metabolism Rodents ROS Signal Transduction - genetics Spleen Succinate dehydrogenase Transgenic mice
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