Improved Laboratory Synthesis of YC-071, a Potent Azole Antifungal Agent

Improved Laboratory Synthesis of YC-071, a Potent Azole Antifungal Agent

An improved laboratory synthesis of YC-071, a potent azole antifungal agent, has been developed. Compared with the original route, the new route is operationally simple, requiring only limited purification of all the intermediates. The new route is an important scalable synthesis, which meets the ne...

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Veröffentlicht in:Journal of chemical research 2017-04, Vol.41 (4), p.241-245
Hauptverfasser: Zheng, Yazhou, Qian, Anran, Ling, Chenyu, Cao, Xufeng, Cui, YongMei, Yang, Yushe
Format: Artikel
Sprache:eng
Schlagworte:
Azoles
Chemical synthesis
Fungicides
Heterocyclic compounds
Purification
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Zusammenfassung:An improved laboratory synthesis of YC-071, a potent azole antifungal agent, has been developed. Compared with the original route, the new route is operationally simple, requiring only limited purification of all the intermediates. The new route is an important scalable synthesis, which meets the need for YC-071 for use in preclinical studies.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751917X14902201357419