NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

The intracellular sensor NLRP12 can negatively regulate inflammation. Ting and colleagues demonstrate that an absence of NLRP12 triggers a dysbiosis that feeds forward into a process of inflammation and colitis. Inflammatory bowel diseases involve the dynamic interaction of host genetics, the microb...

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Veröffentlicht in:	Nature immunology 2017-05, Vol.18 (5), p.541-551
Hauptverfasser:	Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy, Scott E, Young, Vincent B, Sartor, R Balfour, Ting, Jenny P-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262/2106/2517 64/60 692/699/249/2510/257 82/29 96/21 96/31 96/95 Animals Biodiversity Biomedicine Cell receptors Clostridiales - physiology Colitis, Ulcerative - chemically induced Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology Colon - microbiology Colon - physiology Development and progression Dextran Sulfate Feces - microbiology Firmicutes - physiology Gene expression Gene-Environment Interaction Genetic aspects Genetics Health aspects Host-bacteria relationships Humans Immunity, Innate - genetics Immunology Infectious Diseases Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microbiota - genetics Microbiota - immunology RNA, Ribosomal, 16S - analysis Symbiosis Twins, Monozygotic Ulcerative colitis
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