Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases
Background Total liver volume (TLV) empirically changes after aggressive preoperative chemotherapy for colorectal liver metastases (CLM). However, the actual degree of changes in normal liver parenchyma and its clinical relevance remain unclear. Methods Morphometric data of 110 patients who underwen...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2017-05, Vol.21 (5), p.813-821 |
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| creator | Tani, Keigo Shindoh, Junichi Takamoto, Takeshi Shibahara, Junji Nishioka, Yujiro Hashimoto, Takuya Sakamoto, Yoshihiro Hasegawa, Kiyoshi Makuuchi, Masatoshi Kokudo, Norihiro |
| description | Background
Total liver volume (TLV) empirically changes after aggressive preoperative chemotherapy for colorectal liver metastases (CLM). However, the actual degree of changes in normal liver parenchyma and its clinical relevance remain unclear.
Methods
Morphometric data of 110 patients who underwent initial hepatectomy after preoperative chemotherapy were reviewed. TLVs before and after chemotherapy were measured using a computer-based volumetry software and their relevance to clinical factors was investigated.
Results
More than 10% of decrease in TLV was observed in 42 (38.2%) patients, and more than 10% of increase was observed in 11 (10.0%) patients. Change in TLV was within 10% in the remaining 57 (51.8%) patients. Indocyanine green retention rate at 15 min (ICG-R15) value was significantly higher in patients with TLV decrease more than 10% (13.4 vs. 9.3 vs. 8.5%;
p
= 0.004). Steatosis in the underlying liver was significantly frequent in patients with TLV increase more than 10% (
p
15% (odds ratio 8.8;
p
= 0.0001). Tendency of correlation was confirmed in the kinetic changes in TLV and ICG-R15 during chemotherapy even though there was no statistical significance (
r
= −0.33,
p
= 0.080).
Conclusion
Perichemotherapy kinetic changes in TLV may predict histopathologic changes or changes in hepatic functional reserve in the underlying liver. More than 10% of shrinkage in TLV is associated with impaired hepatic functional reserve, and it can be a new supplemental finding in the prediction of surgical risk of major hepatectomy for CLM. |
| doi_str_mv | 10.1007/s11605-017-3359-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1890809407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321898733</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-3266ba05c263516fbc279da15f8cc2ddbfdc646ccdeb28e221f55f9c8b3674943</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotlYfwI0MuB7NZZLJLEvxhhVdKLgLmcyJndK5NEmVvr0ZWsWNEDjJOV_-Ax9C5wRfEYzza0-IwDzFJE8Z40WaHaAxkTlLM0HFYbzjgqSU8_cROvF-iSOIiTxGIyqxZJLlY7R-rFsItUlmC91-gE_qNpnXn-CSF-2gNYtto5OpDUPDQdeD0yGOIw5NFxbx2W8T2w14qKENPvmqwyKZdavOgQl6tU97gqB9POBP0ZHVKw9n-zpBb7c3r7P7dP589zCbzlPDchpSRoUoNeaGCsaJsKWheVFpwq00hlZVaSsjMmFMBSWVQCmxnNvCyJKJPCsyNkGXu9zedesN-KCW3ca1caUissASFxnOI0V2lHGd9w6s6l3daLdVBKtBstpJVtGdGiSrIflin7wpG6h-f_xYjQDdAT6OolX3Z_W_qd-nBYkI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1890809407</pqid></control><display><type>article</type><title>Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tani, Keigo ; Shindoh, Junichi ; Takamoto, Takeshi ; Shibahara, Junji ; Nishioka, Yujiro ; Hashimoto, Takuya ; Sakamoto, Yoshihiro ; Hasegawa, Kiyoshi ; Makuuchi, Masatoshi ; Kokudo, Norihiro</creator><creatorcontrib>Tani, Keigo ; Shindoh, Junichi ; Takamoto, Takeshi ; Shibahara, Junji ; Nishioka, Yujiro ; Hashimoto, Takuya ; Sakamoto, Yoshihiro ; Hasegawa, Kiyoshi ; Makuuchi, Masatoshi ; Kokudo, Norihiro</creatorcontrib><description>Background
Total liver volume (TLV) empirically changes after aggressive preoperative chemotherapy for colorectal liver metastases (CLM). However, the actual degree of changes in normal liver parenchyma and its clinical relevance remain unclear.
Methods
Morphometric data of 110 patients who underwent initial hepatectomy after preoperative chemotherapy were reviewed. TLVs before and after chemotherapy were measured using a computer-based volumetry software and their relevance to clinical factors was investigated.
Results
More than 10% of decrease in TLV was observed in 42 (38.2%) patients, and more than 10% of increase was observed in 11 (10.0%) patients. Change in TLV was within 10% in the remaining 57 (51.8%) patients. Indocyanine green retention rate at 15 min (ICG-R15) value was significantly higher in patients with TLV decrease more than 10% (13.4 vs. 9.3 vs. 8.5%;
p
= 0.004). Steatosis in the underlying liver was significantly frequent in patients with TLV increase more than 10% (
p
< 0.001). Multivariate logistic regression analysis revealed that more than 10% of shrinkage in TLV after chemotherapy was independently associated with ICG-R15 >15% (odds ratio 8.8;
p
= 0.0001). Tendency of correlation was confirmed in the kinetic changes in TLV and ICG-R15 during chemotherapy even though there was no statistical significance (
r
= −0.33,
p
= 0.080).
Conclusion
Perichemotherapy kinetic changes in TLV may predict histopathologic changes or changes in hepatic functional reserve in the underlying liver. More than 10% of shrinkage in TLV is associated with impaired hepatic functional reserve, and it can be a new supplemental finding in the prediction of surgical risk of major hepatectomy for CLM.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-017-3359-4</identifier><identifier>PMID: 28083837</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents - adverse effects ; Chemotherapy ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Coloring Agents ; Female ; Gastroenterology ; Hepatectomy ; Hospitals ; Humans ; Imaging, Three-Dimensional ; Indocyanine Green ; Liver - diagnostic imaging ; Liver - drug effects ; Liver - pathology ; Liver cirrhosis ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoadjuvant Therapy - adverse effects ; Organ Size - drug effects ; Original Article ; Preoperative Care ; Risk Assessment ; Risk Factors ; Software ; Surgery ; Tomography, X-Ray Computed ; Tumors ; Volumetric analysis ; Young Adult</subject><ispartof>Journal of gastrointestinal surgery, 2017-05, Vol.21 (5), p.813-821</ispartof><rights>The Society for Surgery of the Alimentary Tract 2017</rights><rights>Journal of Gastrointestinal Surgery is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3266ba05c263516fbc279da15f8cc2ddbfdc646ccdeb28e221f55f9c8b3674943</citedby><cites>FETCH-LOGICAL-c372t-3266ba05c263516fbc279da15f8cc2ddbfdc646ccdeb28e221f55f9c8b3674943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-017-3359-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-017-3359-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28083837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tani, Keigo</creatorcontrib><creatorcontrib>Shindoh, Junichi</creatorcontrib><creatorcontrib>Takamoto, Takeshi</creatorcontrib><creatorcontrib>Shibahara, Junji</creatorcontrib><creatorcontrib>Nishioka, Yujiro</creatorcontrib><creatorcontrib>Hashimoto, Takuya</creatorcontrib><creatorcontrib>Sakamoto, Yoshihiro</creatorcontrib><creatorcontrib>Hasegawa, Kiyoshi</creatorcontrib><creatorcontrib>Makuuchi, Masatoshi</creatorcontrib><creatorcontrib>Kokudo, Norihiro</creatorcontrib><title>Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
Total liver volume (TLV) empirically changes after aggressive preoperative chemotherapy for colorectal liver metastases (CLM). However, the actual degree of changes in normal liver parenchyma and its clinical relevance remain unclear.
Methods
Morphometric data of 110 patients who underwent initial hepatectomy after preoperative chemotherapy were reviewed. TLVs before and after chemotherapy were measured using a computer-based volumetry software and their relevance to clinical factors was investigated.
Results
More than 10% of decrease in TLV was observed in 42 (38.2%) patients, and more than 10% of increase was observed in 11 (10.0%) patients. Change in TLV was within 10% in the remaining 57 (51.8%) patients. Indocyanine green retention rate at 15 min (ICG-R15) value was significantly higher in patients with TLV decrease more than 10% (13.4 vs. 9.3 vs. 8.5%;
p
= 0.004). Steatosis in the underlying liver was significantly frequent in patients with TLV increase more than 10% (
p
< 0.001). Multivariate logistic regression analysis revealed that more than 10% of shrinkage in TLV after chemotherapy was independently associated with ICG-R15 >15% (odds ratio 8.8;
p
= 0.0001). Tendency of correlation was confirmed in the kinetic changes in TLV and ICG-R15 during chemotherapy even though there was no statistical significance (
r
= −0.33,
p
= 0.080).
Conclusion
Perichemotherapy kinetic changes in TLV may predict histopathologic changes or changes in hepatic functional reserve in the underlying liver. More than 10% of shrinkage in TLV is associated with impaired hepatic functional reserve, and it can be a new supplemental finding in the prediction of surgical risk of major hepatectomy for CLM.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Chemotherapy</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Coloring Agents</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Indocyanine Green</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy - adverse effects</subject><subject>Organ Size - drug effects</subject><subject>Original Article</subject><subject>Preoperative Care</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Software</subject><subject>Surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Volumetric analysis</subject><subject>Young Adult</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0MuB7NZZLJLEvxhhVdKLgLmcyJndK5NEmVvr0ZWsWNEDjJOV_-Ax9C5wRfEYzza0-IwDzFJE8Z40WaHaAxkTlLM0HFYbzjgqSU8_cROvF-iSOIiTxGIyqxZJLlY7R-rFsItUlmC91-gE_qNpnXn-CSF-2gNYtto5OpDUPDQdeD0yGOIw5NFxbx2W8T2w14qKENPvmqwyKZdavOgQl6tU97gqB9POBP0ZHVKw9n-zpBb7c3r7P7dP589zCbzlPDchpSRoUoNeaGCsaJsKWheVFpwq00hlZVaSsjMmFMBSWVQCmxnNvCyJKJPCsyNkGXu9zedesN-KCW3ca1caUissASFxnOI0V2lHGd9w6s6l3daLdVBKtBstpJVtGdGiSrIflin7wpG6h-f_xYjQDdAT6OolX3Z_W_qd-nBYkI</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Tani, Keigo</creator><creator>Shindoh, Junichi</creator><creator>Takamoto, Takeshi</creator><creator>Shibahara, Junji</creator><creator>Nishioka, Yujiro</creator><creator>Hashimoto, Takuya</creator><creator>Sakamoto, Yoshihiro</creator><creator>Hasegawa, Kiyoshi</creator><creator>Makuuchi, Masatoshi</creator><creator>Kokudo, Norihiro</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20170501</creationdate><title>Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases</title><author>Tani, Keigo ; Shindoh, Junichi ; Takamoto, Takeshi ; Shibahara, Junji ; Nishioka, Yujiro ; Hashimoto, Takuya ; Sakamoto, Yoshihiro ; Hasegawa, Kiyoshi ; Makuuchi, Masatoshi ; Kokudo, Norihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3266ba05c263516fbc279da15f8cc2ddbfdc646ccdeb28e221f55f9c8b3674943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Chemotherapy</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Coloring Agents</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Indocyanine Green</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy - adverse effects</topic><topic>Organ Size - drug effects</topic><topic>Original Article</topic><topic>Preoperative Care</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Software</topic><topic>Surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><topic>Volumetric analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tani, Keigo</creatorcontrib><creatorcontrib>Shindoh, Junichi</creatorcontrib><creatorcontrib>Takamoto, Takeshi</creatorcontrib><creatorcontrib>Shibahara, Junji</creatorcontrib><creatorcontrib>Nishioka, Yujiro</creatorcontrib><creatorcontrib>Hashimoto, Takuya</creatorcontrib><creatorcontrib>Sakamoto, Yoshihiro</creatorcontrib><creatorcontrib>Hasegawa, Kiyoshi</creatorcontrib><creatorcontrib>Makuuchi, Masatoshi</creatorcontrib><creatorcontrib>Kokudo, Norihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tani, Keigo</au><au>Shindoh, Junichi</au><au>Takamoto, Takeshi</au><au>Shibahara, Junji</au><au>Nishioka, Yujiro</au><au>Hashimoto, Takuya</au><au>Sakamoto, Yoshihiro</au><au>Hasegawa, Kiyoshi</au><au>Makuuchi, Masatoshi</au><au>Kokudo, Norihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>21</volume><issue>5</issue><spage>813</spage><epage>821</epage><pages>813-821</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
Total liver volume (TLV) empirically changes after aggressive preoperative chemotherapy for colorectal liver metastases (CLM). However, the actual degree of changes in normal liver parenchyma and its clinical relevance remain unclear.
Methods
Morphometric data of 110 patients who underwent initial hepatectomy after preoperative chemotherapy were reviewed. TLVs before and after chemotherapy were measured using a computer-based volumetry software and their relevance to clinical factors was investigated.
Results
More than 10% of decrease in TLV was observed in 42 (38.2%) patients, and more than 10% of increase was observed in 11 (10.0%) patients. Change in TLV was within 10% in the remaining 57 (51.8%) patients. Indocyanine green retention rate at 15 min (ICG-R15) value was significantly higher in patients with TLV decrease more than 10% (13.4 vs. 9.3 vs. 8.5%;
p
= 0.004). Steatosis in the underlying liver was significantly frequent in patients with TLV increase more than 10% (
p
< 0.001). Multivariate logistic regression analysis revealed that more than 10% of shrinkage in TLV after chemotherapy was independently associated with ICG-R15 >15% (odds ratio 8.8;
p
= 0.0001). Tendency of correlation was confirmed in the kinetic changes in TLV and ICG-R15 during chemotherapy even though there was no statistical significance (
r
= −0.33,
p
= 0.080).
Conclusion
Perichemotherapy kinetic changes in TLV may predict histopathologic changes or changes in hepatic functional reserve in the underlying liver. More than 10% of shrinkage in TLV is associated with impaired hepatic functional reserve, and it can be a new supplemental finding in the prediction of surgical risk of major hepatectomy for CLM.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28083837</pmid><doi>10.1007/s11605-017-3359-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of gastrointestinal surgery, 2017-05, Vol.21 (5), p.813-821 |
| issn | 1091-255X 1873-4626 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Chemotherapy Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Coloring Agents Female Gastroenterology Hepatectomy Hospitals Humans Imaging, Three-Dimensional Indocyanine Green Liver - diagnostic imaging Liver - drug effects Liver - pathology Liver cirrhosis Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - secondary Liver Neoplasms - surgery Male Medicine Medicine & Public Health Metastasis Middle Aged Neoadjuvant Therapy - adverse effects Organ Size - drug effects Original Article Preoperative Care Risk Assessment Risk Factors Software Surgery Tomography, X-Ray Computed Tumors Volumetric analysis Young Adult |
| title | Kinetic Changes in Liver Parenchyma After Preoperative Chemotherapy for Patients with Colorectal Liver Metastases |
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