The effects of the HDAC inhibitor sodium butyrate on the expression of repair genes Rad51 and XRCC5 in fibroblast lines mEras-Waf1+/+ and mEras-Waf1

Transformed mice fibroblasts with a knockout CDKN1A gene, which encodes р21/Waf1 protein (mEras-Waf1–/–cells), are characterized by a large number of single-strand DNA breaks and associated γ-H2A.X foci compared to the initial transformant line E1A+cHa-ras (mEras-Waf1+/+ cells). According to immunof...

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Veröffentlicht in:	Cell and tissue biology 2017-03, Vol.11 (2), p.133-140
Hauptverfasser:	Kukushkin, A. N., Svetlikova, S. B., Pospelov, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences CDKN1A gene Cell Biology Chromatin Cyclin-dependent kinase inhibitor p21 Deoxyribonucleic acid DNA DNA damage DNA repair Fibroblasts Genes Histone deacetylase Immunoblotting Immunofluorescence KLF4 protein Life Sciences Nuclei Oct-4 protein Pluripotency Polymerase chain reaction Proteins Rad51 protein Sodium butyrate Transcription activation
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