Optimization of rhBMP-2 active-form production in a heterologous expression system using microbiological and molecular genetic approaches

Recombinant bone morphogenetic protein-2 (rhBMP-2) has pronounced osteoinductive properties, as evidenced by the results of experimental and clinical practices. This applies to both the protein produced in eukaryotic cells and the protein synthesized in bacterial cells. In eukaryotic expression syst...

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