Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report
This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinan...
Gespeichert in:
| Veröffentlicht in: | BioNanoScience 2017-03, Vol.7 (1), p.194-198 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 198 |
|---|---|
| container_issue | 1 |
| container_start_page | 194 |
| container_title | BioNanoScience |
| container_volume | 7 |
| creator | Masgutov, Ruslan Chekunov, Mikhail Zhuravleva, Margarita Masgutova, Galina Teplov, Oleg Salikhov, Ramil Galimov, Damir Plakseichuk, Yuri Rizvanov, Albert |
| description | This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found. |
| doi_str_mv | 10.1007/s12668-016-0325-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1889002650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1889002650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-a53b9a6eb8579281093808bc3e44a590a0a477f539c13eca117d8746cb3322f23</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMoWGp_gLeA59R87ObjWKtWQVCkPYfsdrbdst1dk1Sov96UFfHiXGYG3ved4UHomtEpo1TdBsal1IQySajgOVFnaMSZYYTJzJz_zoJeokkIO5pKUSm0GKFqFQB3FV5AC2RWxvrTRVjje9jXLXjX1F9pu-tawLOm6TbeVRHXLY5bwMttEvTHk3vVtM7jtwCHtfNx67tQhymeu5T9Dn3n4xW6qFwTYPLTx2j1-LCcP5GX18XzfPZCSsFkJC4XhXESCp0rwzWjRmiqi1JAlrncUEddplSVC1MyAaVjTK21ymRZCMF5xcUY3Qy5ve8-DhCi3XUH36aTlmltKOUyp0nFBlWZPg0eKtv7eu_80TJqT0TtQNQmovZE1Krk4YMnJG27Af8n-V_TN_RSd1U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1889002650</pqid></control><display><type>article</type><title>Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report</title><source>SpringerLink Journals</source><creator>Masgutov, Ruslan ; Chekunov, Mikhail ; Zhuravleva, Margarita ; Masgutova, Galina ; Teplov, Oleg ; Salikhov, Ramil ; Galimov, Damir ; Plakseichuk, Yuri ; Rizvanov, Albert</creator><creatorcontrib>Masgutov, Ruslan ; Chekunov, Mikhail ; Zhuravleva, Margarita ; Masgutova, Galina ; Teplov, Oleg ; Salikhov, Ramil ; Galimov, Damir ; Plakseichuk, Yuri ; Rizvanov, Albert</creatorcontrib><description>This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found.</description><identifier>ISSN: 2191-1630</identifier><identifier>EISSN: 2191-1649</identifier><identifier>DOI: 10.1007/s12668-016-0325-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biological and Medical Physics ; Biomaterials ; Biophysics ; Bone grafts ; Bone growth ; Bone matrix ; Bone morphogenetic protein 2 ; Callus ; Case reports ; Circuits and Systems ; Deoxyribonucleic acid ; DNA ; Engineering ; Gene therapy ; Nanotechnology ; Pain ; Surgery ; Ulna ; Vascular endothelial growth factor</subject><ispartof>BioNanoScience, 2017-03, Vol.7 (1), p.194-198</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Copyright Springer Science & Business Media 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-a53b9a6eb8579281093808bc3e44a590a0a477f539c13eca117d8746cb3322f23</citedby><cites>FETCH-LOGICAL-c316t-a53b9a6eb8579281093808bc3e44a590a0a477f539c13eca117d8746cb3322f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12668-016-0325-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12668-016-0325-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Masgutov, Ruslan</creatorcontrib><creatorcontrib>Chekunov, Mikhail</creatorcontrib><creatorcontrib>Zhuravleva, Margarita</creatorcontrib><creatorcontrib>Masgutova, Galina</creatorcontrib><creatorcontrib>Teplov, Oleg</creatorcontrib><creatorcontrib>Salikhov, Ramil</creatorcontrib><creatorcontrib>Galimov, Damir</creatorcontrib><creatorcontrib>Plakseichuk, Yuri</creatorcontrib><creatorcontrib>Rizvanov, Albert</creatorcontrib><title>Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report</title><title>BioNanoScience</title><addtitle>BioNanoSci</addtitle><description>This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found.</description><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biophysics</subject><subject>Bone grafts</subject><subject>Bone growth</subject><subject>Bone matrix</subject><subject>Bone morphogenetic protein 2</subject><subject>Callus</subject><subject>Case reports</subject><subject>Circuits and Systems</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Engineering</subject><subject>Gene therapy</subject><subject>Nanotechnology</subject><subject>Pain</subject><subject>Surgery</subject><subject>Ulna</subject><subject>Vascular endothelial growth factor</subject><issn>2191-1630</issn><issn>2191-1649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMoWGp_gLeA59R87ObjWKtWQVCkPYfsdrbdst1dk1Sov96UFfHiXGYG3ved4UHomtEpo1TdBsal1IQySajgOVFnaMSZYYTJzJz_zoJeokkIO5pKUSm0GKFqFQB3FV5AC2RWxvrTRVjje9jXLXjX1F9pu-tawLOm6TbeVRHXLY5bwMttEvTHk3vVtM7jtwCHtfNx67tQhymeu5T9Dn3n4xW6qFwTYPLTx2j1-LCcP5GX18XzfPZCSsFkJC4XhXESCp0rwzWjRmiqi1JAlrncUEddplSVC1MyAaVjTK21ymRZCMF5xcUY3Qy5ve8-DhCi3XUH36aTlmltKOUyp0nFBlWZPg0eKtv7eu_80TJqT0TtQNQmovZE1Krk4YMnJG27Af8n-V_TN_RSd1U</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Masgutov, Ruslan</creator><creator>Chekunov, Mikhail</creator><creator>Zhuravleva, Margarita</creator><creator>Masgutova, Galina</creator><creator>Teplov, Oleg</creator><creator>Salikhov, Ramil</creator><creator>Galimov, Damir</creator><creator>Plakseichuk, Yuri</creator><creator>Rizvanov, Albert</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170301</creationdate><title>Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report</title><author>Masgutov, Ruslan ; Chekunov, Mikhail ; Zhuravleva, Margarita ; Masgutova, Galina ; Teplov, Oleg ; Salikhov, Ramil ; Galimov, Damir ; Plakseichuk, Yuri ; Rizvanov, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-a53b9a6eb8579281093808bc3e44a590a0a477f539c13eca117d8746cb3322f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biophysics</topic><topic>Bone grafts</topic><topic>Bone growth</topic><topic>Bone matrix</topic><topic>Bone morphogenetic protein 2</topic><topic>Callus</topic><topic>Case reports</topic><topic>Circuits and Systems</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Engineering</topic><topic>Gene therapy</topic><topic>Nanotechnology</topic><topic>Pain</topic><topic>Surgery</topic><topic>Ulna</topic><topic>Vascular endothelial growth factor</topic><toplevel>online_resources</toplevel><creatorcontrib>Masgutov, Ruslan</creatorcontrib><creatorcontrib>Chekunov, Mikhail</creatorcontrib><creatorcontrib>Zhuravleva, Margarita</creatorcontrib><creatorcontrib>Masgutova, Galina</creatorcontrib><creatorcontrib>Teplov, Oleg</creatorcontrib><creatorcontrib>Salikhov, Ramil</creatorcontrib><creatorcontrib>Galimov, Damir</creatorcontrib><creatorcontrib>Plakseichuk, Yuri</creatorcontrib><creatorcontrib>Rizvanov, Albert</creatorcontrib><collection>CrossRef</collection><jtitle>BioNanoScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masgutov, Ruslan</au><au>Chekunov, Mikhail</au><au>Zhuravleva, Margarita</au><au>Masgutova, Galina</au><au>Teplov, Oleg</au><au>Salikhov, Ramil</au><au>Galimov, Damir</au><au>Plakseichuk, Yuri</au><au>Rizvanov, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report</atitle><jtitle>BioNanoScience</jtitle><stitle>BioNanoSci</stitle><date>2017-03-01</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>194</spage><epage>198</epage><pages>194-198</pages><issn>2191-1630</issn><eissn>2191-1649</eissn><abstract>This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12668-016-0325-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2191-1630 |
| ispartof | BioNanoScience, 2017-03, Vol.7 (1), p.194-198 |
| issn | 2191-1630 2191-1649 |
| language | eng |
| recordid | cdi_proquest_journals_1889002650 |
| source | SpringerLink Journals |
| subjects | Biological and Medical Physics Biomaterials Biophysics Bone grafts Bone growth Bone matrix Bone morphogenetic protein 2 Callus Case reports Circuits and Systems Deoxyribonucleic acid DNA Engineering Gene therapy Nanotechnology Pain Surgery Ulna Vascular endothelial growth factor |
| title | Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A39%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20Gene-Activated%20Demineralized%20Bone%20Allograft%20in%20the%20Therapy%20of%20Ulnar%20Pseudarthrosis.%20Case%20Report&rft.jtitle=BioNanoScience&rft.au=Masgutov,%20Ruslan&rft.date=2017-03-01&rft.volume=7&rft.issue=1&rft.spage=194&rft.epage=198&rft.pages=194-198&rft.issn=2191-1630&rft.eissn=2191-1649&rft_id=info:doi/10.1007/s12668-016-0325-7&rft_dat=%3Cproquest_cross%3E1889002650%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1889002650&rft_id=info:pmid/&rfr_iscdi=true |