Inhibition of the K^sub Ca^3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of increasing prevalence marked by poor prognosis and limited treatment options. Ca^sup 2+^-activated K^sub Ca^3.1 potassium channels have been shown to play a key role in the aberrant activation and responses to injury in both ep...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2017-04, Vol.56 (4), p.539
Hauptverfasser:	Organ, Louise, Bacci, Barbara, Koumoundouros, Emmanuel, Kimpton, Wayne G, Samuel, Chrishan S, Nowell, Cameron J, Bradding, Peter, Roach, Katy M, Westall, Glen, Jaffar, Jade, Snibson, Ken J
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Clinical trials Collagen Fibroblasts Growth factors Laboratory animals Lungs Pathology Physiology Pulmonary fibrosis Sheep Studies Wound healing
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