Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

Highlights • Pneumococcal protein antigens could provide serotype-independent protection. • Two PHiD-CV/dPly/PhtD vaccine formulations were assessed in healthy infants. • Both protein-based vaccines elicited immune responses to pneumococcal proteins. • The vaccines had no impact on pneumococcal naso...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2017-05, Vol.35 (19), p.2531-2542
Hauptverfasser:	Odutola, Aderonke, Ota, Martin O.C, Antonio, Martin, Ogundare, Ezra O, Saidu, Yauba, Foster-Nyarko, Ebenezer, Owiafe, Patrick K, Ceesay, Fatima, Worwui, Archibald, Idoko, Olubukola T, Owolabi, Olumuyiwa, Bojang, Abdoulie, Jarju, Sheikh, Drammeh, Isatou, Kampmann, Beate, Greenwood, Brian M, Alderson, Mark, Traskine, Magali, Devos, Nathalie, Schoonbroodt, Sonia, Swinnen, Kristien, Verlant, Vincent, Dobbelaere, Kurt, Borys, Dorota
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Aluminum Antigens Babies Bacteria Bacterial Load Bacterial Proteins - administration & dosage Bacterial Proteins - immunology Bacterial Proteins - toxicity Carrier State - prevention & control Children Combined vaccines Disease Dose-Response Relationship, Immunologic Double-blind studies Effectiveness Female Formulations Gambia Histidine Humans Immune clearance Immune response Immunoglobulins Infant Infants Laboratories Male Nasopharyngeal carriage Nasopharynx - microbiology Pneumococcal histidine triad protein D Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - adverse effects Pneumococcal Vaccines - genetics Pneumococcal Vaccines - immunology Pneumolysin Pneumonia Protein D Proteins Randomization Single-Blind Method Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Streptococcus pneumoniae - isolation & purification Treatment Outcome Vaccine efficacy Vaccines Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Pneumococcal protein antigens could provide serotype-independent protection. • Two PHiD-CV/dPly/PhtD vaccine formulations were assessed in healthy infants. • Both protein-based vaccines elicited immune responses to pneumococcal proteins. • The vaccines had no impact on pneumococcal nasopharyngeal carriage prevalence. • Future evaluations will assess their impact against pneumococcal disease endpoints.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.03.071