Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3Н)-one

Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3Н)-one

The application of bis-(4-nitrophenyl)phosphorylazide–1,8-diazabicyclo[5.4.0]undec-7-ene system for direct transformation of polyfunctional derivatives of pyrimidin-4(3 H )-one in the corresponding 4-azidopyrimidines has been suggested for the first time. Using this system, novel 4-azido-6-(2,6-diha...

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Veröffentlicht in:Russian journal of general chemistry 2017-02, Vol.87 (2), p.219-223
Hauptverfasser: Novakov, I. A., Babushkin, A. S., Brunilina, L. L., Navrotskii, M. B., Orlinson, B. S., Robinovich, M. D., Yablokov, A. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Reagents
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Zusammenfassung:The application of bis-(4-nitrophenyl)phosphorylazide–1,8-diazabicyclo[5.4.0]undec-7-ene system for direct transformation of polyfunctional derivatives of pyrimidin-4(3 H )-one in the corresponding 4-azidopyrimidines has been suggested for the first time. Using this system, novel 4-azido-6-(2,6-dihalo-α-methoxybenzyl)-5-methyl-2-(nitroamino)pyrimidines have been obtained in good yield under mild conditions.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217020116