AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL GLAND
Angiotensin II binding sites in human adrenal glands obtained at autopsy were investigated. The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made...
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| Veröffentlicht in: | Biomedical Research 1988/02/01, Vol.9(1), pp.27-31 |
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| container_end_page | 31 |
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| container_start_page | 27 |
| container_title | Biomedical Research |
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| creator | SHIGEMATSU, KAZUTO NIWA, MASAMI SHIMOMURA, CHIEKO OHTA, HISASHI TSUCHIYAMA, HIDEO OZAKI, MASAYORI |
| description | Angiotensin II binding sites in human adrenal glands obtained at autopsy were investigated. The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made with 125I-standards. A single type of specific, high affinity binding sites was found in the zona glomerulosa and medulla. The rank order for inhibition of the binding in the zona glomerulosa and medulla was [Sar1, Ile8]-angiotensin II and Des-Asp1-[Ile8]angiotensin II > native angiotensin II = angiotensin III >>> angiotensin I, αhuman atrial natriuretic polypeptide (ANP-(99-126)), substance P and methionineenkephalin. The possibility that angiotensin II plays a significant role in function of the human adrenal zona glomerulosa and medulla by interacting with specific, high affinity receptors, Warrants further attention. |
| doi_str_mv | 10.2220/biomedres.9.27 |
| format | Article |
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The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made with 125I-standards. A single type of specific, high affinity binding sites was found in the zona glomerulosa and medulla. The rank order for inhibition of the binding in the zona glomerulosa and medulla was [Sar1, Ile8]-angiotensin II and Des-Asp1-[Ile8]angiotensin II > native angiotensin II = angiotensin III >>> angiotensin I, αhuman atrial natriuretic polypeptide (ANP-(99-126)), substance P and methionineenkephalin. The possibility that angiotensin II plays a significant role in function of the human adrenal zona glomerulosa and medulla by interacting with specific, high affinity receptors, Warrants further attention.</description><identifier>ISSN: 0388-6107</identifier><identifier>EISSN: 1880-313X</identifier><identifier>DOI: 10.2220/biomedres.9.27</identifier><language>eng</language><publisher>Sapporo: Biomedical Research Press</publisher><subject>Adrenal glands ; Affinity ; Angiotensin ; Angiotensin I ; Angiotensin II ; Angiotensin III ; Autopsies ; Autopsy ; Autoradiography ; Binding sites ; Image analysis ; Image processing ; Medulla oblongata ; Receptors ; Substance P</subject><ispartof>Biomedical Research, 1988/02/01, Vol.9(1), pp.27-31</ispartof><rights>1988 Biomedical Research Press</rights><rights>Copyright Japan Science and Technology Agency 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-ee336b59365f0a31e55786befa9aa215db08cba49b8d02f8fd5959defa4c8083</citedby><cites>FETCH-LOGICAL-c485t-ee336b59365f0a31e55786befa9aa215db08cba49b8d02f8fd5959defa4c8083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>SHIGEMATSU, KAZUTO</creatorcontrib><creatorcontrib>NIWA, MASAMI</creatorcontrib><creatorcontrib>SHIMOMURA, CHIEKO</creatorcontrib><creatorcontrib>OHTA, HISASHI</creatorcontrib><creatorcontrib>TSUCHIYAMA, HIDEO</creatorcontrib><creatorcontrib>OZAKI, MASAYORI</creatorcontrib><title>AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL GLAND</title><title>Biomedical Research</title><addtitle>Biomed. Res.</addtitle><description>Angiotensin II binding sites in human adrenal glands obtained at autopsy were investigated. The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made with 125I-standards. A single type of specific, high affinity binding sites was found in the zona glomerulosa and medulla. The rank order for inhibition of the binding in the zona glomerulosa and medulla was [Sar1, Ile8]-angiotensin II and Des-Asp1-[Ile8]angiotensin II > native angiotensin II = angiotensin III >>> angiotensin I, αhuman atrial natriuretic polypeptide (ANP-(99-126)), substance P and methionineenkephalin. The possibility that angiotensin II plays a significant role in function of the human adrenal zona glomerulosa and medulla by interacting with specific, high affinity receptors, Warrants further attention.</description><subject>Adrenal glands</subject><subject>Affinity</subject><subject>Angiotensin</subject><subject>Angiotensin I</subject><subject>Angiotensin II</subject><subject>Angiotensin III</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Autoradiography</subject><subject>Binding sites</subject><subject>Image analysis</subject><subject>Image processing</subject><subject>Medulla oblongata</subject><subject>Receptors</subject><subject>Substance P</subject><issn>0388-6107</issn><issn>1880-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNpVkL1PwzAQxS0EEqWwMltiTrDjuHE2TJKmloqD2hSxWU7iQKt-YacD_z0pRZWYTnfv9-50D4B7jPwgCNBjtdxtTGON82M_iC7AADOGPILJ-yUYIMKYN8IougY3zq1Q32NGBqDki7KY8VQU-Yy_TkQCszeRZjLJYDGGXOaiKDM5FxIKAZ-FTIXM4VyU2Rz2s3KSwcnihUvI01km-RTmUy7TW3DV6rUzd391CMpxViYTb1rkIuFTrw4Z7TxjCBlVNCYj2iJNsKE0YqPKtDrWOsC0qRCrKx3GFWtQ0LK2oTGNm14Pa4YYGYKH09q93X0djOvUanew2_6i6l8PaRiF0ZHyT1Rtd85Z06q9XW60_VYYqWNw6hycilUQ9Yank2HlOv1hzri23bJem384_rWcpfpTW2W25AdvAnQh</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>SHIGEMATSU, KAZUTO</creator><creator>NIWA, MASAMI</creator><creator>SHIMOMURA, CHIEKO</creator><creator>OHTA, HISASHI</creator><creator>TSUCHIYAMA, HIDEO</creator><creator>OZAKI, MASAYORI</creator><general>Biomedical Research Press</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>1988</creationdate><title>AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL GLAND</title><author>SHIGEMATSU, KAZUTO ; NIWA, MASAMI ; SHIMOMURA, CHIEKO ; OHTA, HISASHI ; TSUCHIYAMA, HIDEO ; OZAKI, MASAYORI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-ee336b59365f0a31e55786befa9aa215db08cba49b8d02f8fd5959defa4c8083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenal glands</topic><topic>Affinity</topic><topic>Angiotensin</topic><topic>Angiotensin I</topic><topic>Angiotensin II</topic><topic>Angiotensin III</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Autoradiography</topic><topic>Binding sites</topic><topic>Image analysis</topic><topic>Image processing</topic><topic>Medulla oblongata</topic><topic>Receptors</topic><topic>Substance P</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIGEMATSU, KAZUTO</creatorcontrib><creatorcontrib>NIWA, MASAMI</creatorcontrib><creatorcontrib>SHIMOMURA, CHIEKO</creatorcontrib><creatorcontrib>OHTA, HISASHI</creatorcontrib><creatorcontrib>TSUCHIYAMA, HIDEO</creatorcontrib><creatorcontrib>OZAKI, MASAYORI</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biomedical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIGEMATSU, KAZUTO</au><au>NIWA, MASAMI</au><au>SHIMOMURA, CHIEKO</au><au>OHTA, HISASHI</au><au>TSUCHIYAMA, HIDEO</au><au>OZAKI, MASAYORI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL GLAND</atitle><jtitle>Biomedical Research</jtitle><addtitle>Biomed. Res.</addtitle><date>1988</date><risdate>1988</risdate><volume>9</volume><issue>1</issue><spage>27</spage><epage>31</epage><pages>27-31</pages><issn>0388-6107</issn><eissn>1880-313X</eissn><abstract>Angiotensin II binding sites in human adrenal glands obtained at autopsy were investigated. The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made with 125I-standards. A single type of specific, high affinity binding sites was found in the zona glomerulosa and medulla. The rank order for inhibition of the binding in the zona glomerulosa and medulla was [Sar1, Ile8]-angiotensin II and Des-Asp1-[Ile8]angiotensin II > native angiotensin II = angiotensin III >>> angiotensin I, αhuman atrial natriuretic polypeptide (ANP-(99-126)), substance P and methionineenkephalin. The possibility that angiotensin II plays a significant role in function of the human adrenal zona glomerulosa and medulla by interacting with specific, high affinity receptors, Warrants further attention.</abstract><cop>Sapporo</cop><pub>Biomedical Research Press</pub><doi>10.2220/biomedres.9.27</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0388-6107 |
| ispartof | Biomedical Research, 1988/02/01, Vol.9(1), pp.27-31 |
| issn | 0388-6107 1880-313X |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adrenal glands Affinity Angiotensin Angiotensin I Angiotensin II Angiotensin III Autopsies Autopsy Autoradiography Binding sites Image analysis Image processing Medulla oblongata Receptors Substance P |
| title | AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL GLAND |
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