Macrophages induce AKT/[beta]-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through...

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Veröffentlicht in:	Nature communications 2017-03, Vol.8, p.14091
Hauptverfasser:	Wang, Xusheng, Chen, Haiyan, Tian, Ruiyun, Zhang, Yiling, Drutskaya, Marina S, Wang, Chengmei, Ge, Jianfeng, Fan, Zhimeng, Kong, Deqiang, Wang, Xiaoxiao, Cai, Ting, Zhou, Ying, Wang, Jingwen, Wang, Jinmei, Wang, Shan, Qin, Zhihai, Jia, Huanhuan, Wu, Yue, Liu, Jia, Nedospasov, Sergei A, Tredget, Edward E, Lin, Mei, Liu, Jianjun, Jiang, Yuyang, Wu, Yaojiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Follicles Kinases Laboratory animals Life sciences Stem cells Tumor necrosis factor-TNF Wound healing
Online-Zugang:	Volltext
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